Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation
Ischemic stroke is a leading cause of death and disability worldwide. Following an ischemic insult, cells undergo endoplasmic reticulum (ER) stress, which increases the ER’s protein-folding and degradative capacities and blocks the global synthesis of proteins by phosphorylating the eukaryotic trans...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/3747 |
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| author | Marta Aramburu-Núñez Antía Custodia María Pérez-Mato Ramón Iglesias-Rey Francisco Campos José Castillo Alberto Ouro Daniel Romaus-Sanjurjo Tomás Sobrino |
| author_facet | Marta Aramburu-Núñez Antía Custodia María Pérez-Mato Ramón Iglesias-Rey Francisco Campos José Castillo Alberto Ouro Daniel Romaus-Sanjurjo Tomás Sobrino |
| author_sort | Marta Aramburu-Núñez |
| collection | DOAJ |
| description | Ischemic stroke is a leading cause of death and disability worldwide. Following an ischemic insult, cells undergo endoplasmic reticulum (ER) stress, which increases the ER’s protein-folding and degradative capacities and blocks the global synthesis of proteins by phosphorylating the eukaryotic translation initiation factor 2-alpha (eIF2α). Phosphorylation of eIF2α is directly related to the dynamics of stress granules (SGs), which are membraneless organelles composed of RNA-binding proteins and mRNA. SGs play a critical role in mRNA metabolism and translational control. Other translation factors are also linked to cellular pathways, including SG dynamics following a stroke. Because the formation of SGs is closely connected to mRNA translation, it is interesting to study the relationship between SG dynamics and cellular outcome in cases of ischemic damage. Therefore, in this review, we focus on the role of SG dynamics during cerebral ischemia. |
| first_indexed | 2024-03-09T11:46:53Z |
| format | Article |
| id | doaj.art-cdfcbee7b3984c61bd56f85c878273bf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:46:53Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cdfcbee7b3984c61bd56f85c878273bf2023-11-30T23:21:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237374710.3390/ijms23073747Stress Granules and Acute Ischemic Stroke: Beyond mRNA TranslationMarta Aramburu-Núñez0Antía Custodia1María Pérez-Mato2Ramón Iglesias-Rey3Francisco Campos4José Castillo5Alberto Ouro6Daniel Romaus-Sanjurjo7Tomás Sobrino8NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, SpainNeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, SpainNeurological Sciences and Cerebrovascular Research Laboratory, Department of Neurology and Stroke Center, La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Universidad Autónoma de Madrid, 28046 Madrid, SpainNeuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, SpainTranslational Stroke Laboratory Group (TREAT), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, SpainNeuroimaging and Biotechnology Laboratory (NOBEL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, SpainNeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, SpainNeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, SpainNeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, SpainIschemic stroke is a leading cause of death and disability worldwide. Following an ischemic insult, cells undergo endoplasmic reticulum (ER) stress, which increases the ER’s protein-folding and degradative capacities and blocks the global synthesis of proteins by phosphorylating the eukaryotic translation initiation factor 2-alpha (eIF2α). Phosphorylation of eIF2α is directly related to the dynamics of stress granules (SGs), which are membraneless organelles composed of RNA-binding proteins and mRNA. SGs play a critical role in mRNA metabolism and translational control. Other translation factors are also linked to cellular pathways, including SG dynamics following a stroke. Because the formation of SGs is closely connected to mRNA translation, it is interesting to study the relationship between SG dynamics and cellular outcome in cases of ischemic damage. Therefore, in this review, we focus on the role of SG dynamics during cerebral ischemia.https://www.mdpi.com/1422-0067/23/7/3747endothelial celleukaryotic initiation factor 2eukaryotic initiation factor 4Fhippocampusischemianeuron |
| spellingShingle | Marta Aramburu-Núñez Antía Custodia María Pérez-Mato Ramón Iglesias-Rey Francisco Campos José Castillo Alberto Ouro Daniel Romaus-Sanjurjo Tomás Sobrino Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation International Journal of Molecular Sciences endothelial cell eukaryotic initiation factor 2 eukaryotic initiation factor 4F hippocampus ischemia neuron |
| title | Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation |
| title_full | Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation |
| title_fullStr | Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation |
| title_full_unstemmed | Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation |
| title_short | Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation |
| title_sort | stress granules and acute ischemic stroke beyond mrna translation |
| topic | endothelial cell eukaryotic initiation factor 2 eukaryotic initiation factor 4F hippocampus ischemia neuron |
| url | https://www.mdpi.com/1422-0067/23/7/3747 |
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