CTL-Derived Exosomes Enhance the Activation of CTLs Stimulated by Low-Affinity Peptides

CTL-Derived Exosomes Enhance the Activation of CTLs Stimulated by Low-Affinity Peptides

Cytotoxic T cells (CTLs) bind to peptides presented by MHC I (pMHC) through T cell receptors of various affinities. Low-affinity CTLs are important for the control of intracellular pathogens and cancers; however, the mechanisms by which these lower affinity CTLs are activated and maintained are not...

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Bibliographic Details
Main Authors: Shu-Wei Wu, Lei Li, Yan Wang, Zhengguo Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
CTLs
IL-12
exosomes
activation
low-affinity
N4 peptides
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01274/full

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