Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up
We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contr...
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MDPI AG
2021-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/11/1276 |
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| author | Izabella Karska-Basta Bożena Romanowska-Dixon Dorota Pojda-Wilczek Alina Bakunowicz-Łazarczyk Agnieszka Kubicka-Trząska Karolina Gerba-Górecka |
| author_facet | Izabella Karska-Basta Bożena Romanowska-Dixon Dorota Pojda-Wilczek Alina Bakunowicz-Łazarczyk Agnieszka Kubicka-Trząska Karolina Gerba-Górecka |
| author_sort | Izabella Karska-Basta |
| collection | DOAJ |
| description | We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contribute to an inflammatory response both in the brain and the retina. A 13-year-old male patient with epilepsy was referred by a neurologist for an ophthalmologic consultation due to a sudden deterioration of visual acuity in the left eye. The examination, with a key role of multimodal imaging including color fundus photography, fluorescein angiography, indocyanine green angiography (ICGA), fundus autofluorescence (FAF), swept-source optical coherence tomography (SS-OCT) with visual field assessment, and electroretinography indicated AZOOR as the underlying entity. Findings at the first admission included enlargement of the blind spot in visual field examination along a typical trizonal pattern, which was revealed by FAF, ICGA, and SS-OCT in the left eye. The right eye exhibited no abnormalities. Seminal follow-up revealed no changes in best corrected visual acuity, and multimodal imaging findings remain unaltered. Thus, no medical intervention is required. Our case and recent laboratory findings suggest a causative link between epilepsy and retinal disorders, although this issue requires further research. |
| first_indexed | 2024-03-10T05:18:13Z |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T05:18:13Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-cdffc6f5614d4819bc7cde5298f0f87c2023-11-23T00:18:24ZengMDPI AGMedicina1010-660X1648-91442021-11-015711127610.3390/medicina57111276Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-UpIzabella Karska-Basta0Bożena Romanowska-Dixon1Dorota Pojda-Wilczek2Alina Bakunowicz-Łazarczyk3Agnieszka Kubicka-Trząska4Karolina Gerba-Górecka5Division of Ophthalmology and Ocular Oncology, Department of Ophthalmology, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, PolandDivision of Ophthalmology and Ocular Oncology, Department of Ophthalmology, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, PolandDepartment of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, PolandDepartment of Pediatric Ophthalmology and Strabismus, Medical University of Białystok, Białystok University Children’s Hospital, 15-274 Białystok, PolandDivision of Ophthalmology and Ocular Oncology, Department of Ophthalmology, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Kraków, PolandDepartment of Opthalmology and Ocular Oncology, University Hospital, 31-501 Kraków, PolandWe report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it has been established that epileptic episodes contribute to an inflammatory response both in the brain and the retina. A 13-year-old male patient with epilepsy was referred by a neurologist for an ophthalmologic consultation due to a sudden deterioration of visual acuity in the left eye. The examination, with a key role of multimodal imaging including color fundus photography, fluorescein angiography, indocyanine green angiography (ICGA), fundus autofluorescence (FAF), swept-source optical coherence tomography (SS-OCT) with visual field assessment, and electroretinography indicated AZOOR as the underlying entity. Findings at the first admission included enlargement of the blind spot in visual field examination along a typical trizonal pattern, which was revealed by FAF, ICGA, and SS-OCT in the left eye. The right eye exhibited no abnormalities. Seminal follow-up revealed no changes in best corrected visual acuity, and multimodal imaging findings remain unaltered. Thus, no medical intervention is required. Our case and recent laboratory findings suggest a causative link between epilepsy and retinal disorders, although this issue requires further research.https://www.mdpi.com/1648-9144/57/11/1276AZOORepilepsyelectrophysiology |
| spellingShingle | Izabella Karska-Basta Bożena Romanowska-Dixon Dorota Pojda-Wilczek Alina Bakunowicz-Łazarczyk Agnieszka Kubicka-Trząska Karolina Gerba-Górecka Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up Medicina AZOOR epilepsy electrophysiology |
| title | Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up |
| title_full | Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up |
| title_fullStr | Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up |
| title_full_unstemmed | Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up |
| title_short | Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up |
| title_sort | acute zonal occult outer retinopathy in a patient suffering from epilepsy five year follow up |
| topic | AZOOR epilepsy electrophysiology |
| url | https://www.mdpi.com/1648-9144/57/11/1276 |
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