Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learning
Previous evidence shows a reliable association between psychosis-prone (especially schizotypal) personality traits and performance on dopamine (DA)-sensitive tasks (e.g., prepulse inhibition and antisaccade). Here, we used blood oxygen level dependent (BOLD) fMRI and an established procedural learni...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-04-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00130/full |
| _version_ | 1818017719572758528 |
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| author | Ulrich eEttinger Ulrich eEttinger Philip J Corr Ardeshier eMofidi Steven CR Williams Veena eKumari Veena eKumari |
| author_facet | Ulrich eEttinger Ulrich eEttinger Philip J Corr Ardeshier eMofidi Steven CR Williams Veena eKumari Veena eKumari |
| author_sort | Ulrich eEttinger |
| collection | DOAJ |
| description | Previous evidence shows a reliable association between psychosis-prone (especially schizotypal) personality traits and performance on dopamine (DA)-sensitive tasks (e.g., prepulse inhibition and antisaccade). Here, we used blood oxygen level dependent (BOLD) fMRI and an established procedural learning task to examine the dopaminergic basis of two aspects of psychosis-proneness (specific schizotypy and general psychoticism). Thirty healthy participants (final N=26) underwent fMRI during a blocked, periodic sequence-learning task which, in previous studies, has been shown to reveal impaired performance in schizophrenia patients given drugs blocking the DA D2 receptor subtype (DRD2), and to correspond with manipulation of DA activity and elicit fronto-striatal-cerebellar activity in healthy people. Psychosis-proneness was indexed by the Psychoticism scale of the Eysenck Personality Questionnaire-Revised (EPQ-R; 1991) and the Schizotypal Personality Scale (STA; 1984). EPQ-R Extraversion and Neuroticism scores were also examined to establish discriminant validity. We found a positive correlation between the two psychosis-proneness measures (r=0.43), and a robust and unique positive association between EPQ-R Psychoticism and BOLD signal in the putamen, caudate, thalamus, insula and frontal regions. STA schizotypy score correlated positively with activity in the right middle temporal gyrus. As DA is a key transmitter in the basal ganglia, and the thalamus contains the highest levels of DRD2 receptors of all extrastriatal regions, our results support a dopaminergic basis of psychosis-proneness as measured by the EPQ-R Psychoticism. |
| first_indexed | 2024-04-14T07:30:33Z |
| format | Article |
| id | doaj.art-ce01273d36f84b819285512b9b4f204e |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-14T07:30:33Z |
| publishDate | 2013-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-ce01273d36f84b819285512b9b4f204e2022-12-22T02:05:53ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612013-04-01710.3389/fnhum.2013.0013042673Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learningUlrich eEttinger0Ulrich eEttinger1Philip J Corr2Ardeshier eMofidi3Steven CR Williams4Veena eKumari5Veena eKumari6University of BonnKing's College LondonCity University King's College LondonKing's College LondonKing's College LondonNIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry and South London and Maudsley NHS TrustPrevious evidence shows a reliable association between psychosis-prone (especially schizotypal) personality traits and performance on dopamine (DA)-sensitive tasks (e.g., prepulse inhibition and antisaccade). Here, we used blood oxygen level dependent (BOLD) fMRI and an established procedural learning task to examine the dopaminergic basis of two aspects of psychosis-proneness (specific schizotypy and general psychoticism). Thirty healthy participants (final N=26) underwent fMRI during a blocked, periodic sequence-learning task which, in previous studies, has been shown to reveal impaired performance in schizophrenia patients given drugs blocking the DA D2 receptor subtype (DRD2), and to correspond with manipulation of DA activity and elicit fronto-striatal-cerebellar activity in healthy people. Psychosis-proneness was indexed by the Psychoticism scale of the Eysenck Personality Questionnaire-Revised (EPQ-R; 1991) and the Schizotypal Personality Scale (STA; 1984). EPQ-R Extraversion and Neuroticism scores were also examined to establish discriminant validity. We found a positive correlation between the two psychosis-proneness measures (r=0.43), and a robust and unique positive association between EPQ-R Psychoticism and BOLD signal in the putamen, caudate, thalamus, insula and frontal regions. STA schizotypy score correlated positively with activity in the right middle temporal gyrus. As DA is a key transmitter in the basal ganglia, and the thalamus contains the highest levels of DRD2 receptors of all extrastriatal regions, our results support a dopaminergic basis of psychosis-proneness as measured by the EPQ-R Psychoticism.http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00130/fullDopamineThalamussequence learningStriatumschizotypy |
| spellingShingle | Ulrich eEttinger Ulrich eEttinger Philip J Corr Ardeshier eMofidi Steven CR Williams Veena eKumari Veena eKumari Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learning Frontiers in Human Neuroscience Dopamine Thalamus sequence learning Striatum schizotypy |
| title | Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learning |
| title_full | Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learning |
| title_fullStr | Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learning |
| title_full_unstemmed | Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learning |
| title_short | Dopaminergic basis of the psychosis-prone personality investigated with functional magnetic resonance imaging of procedural learning |
| title_sort | dopaminergic basis of the psychosis prone personality investigated with functional magnetic resonance imaging of procedural learning |
| topic | Dopamine Thalamus sequence learning Striatum schizotypy |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00130/full |
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