Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis
Abstract Background The impact of anemia treatment with erythropoietin stimulating agents (ESA) on health-related quality of life (HRQOL) in chronic kidney disease (CKD) patients is controversial, particularly regarding optimal hemoglobin (Hb) target ranges. Methods We conducted a systematic review...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-020-01912-8 |
| _version_ | 1819001697614168064 |
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| author | Murilo Guedes Camila R. Guetter Lucas H. O. Erbano Andre G. Palone Jarcy Zee Bruce M. Robinson Ronald Pisoni Thyago Proença de Moraes Roberto Pecoits-Filho Cristina P. Baena |
| author_facet | Murilo Guedes Camila R. Guetter Lucas H. O. Erbano Andre G. Palone Jarcy Zee Bruce M. Robinson Ronald Pisoni Thyago Proença de Moraes Roberto Pecoits-Filho Cristina P. Baena |
| author_sort | Murilo Guedes |
| collection | DOAJ |
| description | Abstract Background The impact of anemia treatment with erythropoietin stimulating agents (ESA) on health-related quality of life (HRQOL) in chronic kidney disease (CKD) patients is controversial, particularly regarding optimal hemoglobin (Hb) target ranges. Methods We conducted a systematic review and meta-analysis of observational studies and randomized controlled trials (RCT) with ESA to estimate the effect of different achieved Hb values on physical HRQOL and functionality. We searched PubMed, EMBASE, CENTRAL, PEDro, PsycINFO and Web of Science databases, until May 2020. Two authors independently extracted data from studies. We included observational and RCTs that enrolled CKD patients undergoing anemia treatment with ESA with different achieved Hb levels among groups. We excluded studies with achieved Hb < 9 g/dL. For the meta-analysis, we included RCTs with control groups achieving Hb 10–11.5 g/dL and active groups with Hb > 11.5 g/dL. We analyzed the standardized mean difference (SMD) between groups for physical HRQOL. Results Among 8496 studies, fifteen RCTs and five observational studies were included for the systematic review. We performed the meta-analysis in a subset of eleven eligible RCTs. For physical role and physical function, SMDs were 0.0875 [95% CI: − 0.0025 – 0.178] and 0.08 [95% CI: − 0.03 – 0.19], respectively. For fatigue, SMD was 0.16 [95% CI: 0.09–0.24]. Subgroup analysis showed that trials with greater achieved Hb had greater pooled effects sizes — 0.21 [95% CI: 0.07–0.36] for Hb > 13 g/dL vs. 0.09 [95% CI: 0.02–0.16] for Hb 11.5–13 g/dL. Proportion of older and long-term diabetic patients across studies were associated with lower effect sizes. Conclusion Achieved hemoglobin higher than currently recommended targets may be associated with small but potentially clinically significant improvement in fatigue, but not in physical role or physical function. Younger and non-diabetic patients may experience more pronounced benefits of higher Hb levels after treatment with ESAs. |
| first_indexed | 2024-12-20T22:53:20Z |
| format | Article |
| id | doaj.art-ce0163a86c1b401f899d022dcddabdc6 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-20T22:53:20Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-ce0163a86c1b401f899d022dcddabdc62022-12-21T19:24:10ZengBMCBMC Nephrology1471-23692020-07-0121111510.1186/s12882-020-01912-8Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysisMurilo Guedes0Camila R. Guetter1Lucas H. O. Erbano2Andre G. Palone3Jarcy Zee4Bruce M. Robinson5Ronald Pisoni6Thyago Proença de Moraes7Roberto Pecoits-Filho8Cristina P. Baena9Pontifícia Universidade Católica do ParanáUniversidade Federal do ParanáPontifícia Universidade Católica do ParanáPontifícia Universidade Católica do ParanáArbor Research Collaborative for HealthArbor Research Collaborative for HealthArbor Research Collaborative for HealthPontifícia Universidade Católica do ParanáPontifícia Universidade Católica do ParanáPontifícia Universidade Católica do ParanáAbstract Background The impact of anemia treatment with erythropoietin stimulating agents (ESA) on health-related quality of life (HRQOL) in chronic kidney disease (CKD) patients is controversial, particularly regarding optimal hemoglobin (Hb) target ranges. Methods We conducted a systematic review and meta-analysis of observational studies and randomized controlled trials (RCT) with ESA to estimate the effect of different achieved Hb values on physical HRQOL and functionality. We searched PubMed, EMBASE, CENTRAL, PEDro, PsycINFO and Web of Science databases, until May 2020. Two authors independently extracted data from studies. We included observational and RCTs that enrolled CKD patients undergoing anemia treatment with ESA with different achieved Hb levels among groups. We excluded studies with achieved Hb < 9 g/dL. For the meta-analysis, we included RCTs with control groups achieving Hb 10–11.5 g/dL and active groups with Hb > 11.5 g/dL. We analyzed the standardized mean difference (SMD) between groups for physical HRQOL. Results Among 8496 studies, fifteen RCTs and five observational studies were included for the systematic review. We performed the meta-analysis in a subset of eleven eligible RCTs. For physical role and physical function, SMDs were 0.0875 [95% CI: − 0.0025 – 0.178] and 0.08 [95% CI: − 0.03 – 0.19], respectively. For fatigue, SMD was 0.16 [95% CI: 0.09–0.24]. Subgroup analysis showed that trials with greater achieved Hb had greater pooled effects sizes — 0.21 [95% CI: 0.07–0.36] for Hb > 13 g/dL vs. 0.09 [95% CI: 0.02–0.16] for Hb 11.5–13 g/dL. Proportion of older and long-term diabetic patients across studies were associated with lower effect sizes. Conclusion Achieved hemoglobin higher than currently recommended targets may be associated with small but potentially clinically significant improvement in fatigue, but not in physical role or physical function. Younger and non-diabetic patients may experience more pronounced benefits of higher Hb levels after treatment with ESAs.http://link.springer.com/article/10.1186/s12882-020-01912-8AnemiaChronic kidney diseaseHealth-related quality of life |
| spellingShingle | Murilo Guedes Camila R. Guetter Lucas H. O. Erbano Andre G. Palone Jarcy Zee Bruce M. Robinson Ronald Pisoni Thyago Proença de Moraes Roberto Pecoits-Filho Cristina P. Baena Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis BMC Nephrology Anemia Chronic kidney disease Health-related quality of life |
| title | Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis |
| title_full | Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis |
| title_fullStr | Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis |
| title_full_unstemmed | Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis |
| title_short | Physical health-related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients: a systematic review and meta-analysis |
| title_sort | physical health related quality of life at higher achieved hemoglobin levels among chronic kidney disease patients a systematic review and meta analysis |
| topic | Anemia Chronic kidney disease Health-related quality of life |
| url | http://link.springer.com/article/10.1186/s12882-020-01912-8 |
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