Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
Predicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.00848/full |
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| author | Alvaro Fuertes Alvaro Fuertes Sergio Pérez-Burillo Iñigo Apaolaza Iñigo Apaolaza Yvonne Vallès Yvonne Vallès M. Pilar Francino M. Pilar Francino José Ángel Rufián-Henares José Ángel Rufián-Henares Francisco J. Planes Francisco J. Planes |
| author_facet | Alvaro Fuertes Alvaro Fuertes Sergio Pérez-Burillo Iñigo Apaolaza Iñigo Apaolaza Yvonne Vallès Yvonne Vallès M. Pilar Francino M. Pilar Francino José Ángel Rufián-Henares José Ángel Rufián-Henares Francisco J. Planes Francisco J. Planes |
| author_sort | Alvaro Fuertes |
| collection | DOAJ |
| description | Predicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic assignments of meta-omics data. In this work, this algorithm is applied to elucidate the metabolic changes induced over the first year after birth in the gut microbiota of a cohort of Spanish infants. We used metagenomics data of fecal samples and nutritional data of 13 infants at five time points. The resulting networks for each time point were analyzed, finding significant alterations once solid food is introduced in the diet. Our work shows that solid food leads to a different pattern of output metabolites that can be potentially released from the gut microbiota to the host. Experimental validation is presented for ferulate, a neuroprotective metabolite involved in the gut-brain axis. |
| first_indexed | 2024-12-10T17:15:55Z |
| format | Article |
| id | doaj.art-ce049b95dec547ceaaf465f53fc2d253 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-10T17:15:55Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ce049b95dec547ceaaf465f53fc2d2532022-12-22T01:40:08ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-04-011010.3389/fmicb.2019.00848442159Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After BirthAlvaro Fuertes0Alvaro Fuertes1Sergio Pérez-Burillo2Iñigo Apaolaza3Iñigo Apaolaza4Yvonne Vallès5Yvonne Vallès6M. Pilar Francino7M. Pilar Francino8José Ángel Rufián-Henares9José Ángel Rufián-Henares10Francisco J. Planes11Francisco J. Planes12Bioinformatics Group, TECNUN School of Engineering, Department of Biomedical Engineering and Sciences, Universidad de Navarra, San Sebastián, SpainBioinformatics Group, CEIT, Water and Health Division, Universidad de Navarra, San Sebastián, SpainDepartamento de Nutrición y Bromatología, Instituto de Nutrición y Tecnología de los Alimentos, Centro de Investigación Biomédica, Universidad de Granada, Granada, SpainBioinformatics Group, TECNUN School of Engineering, Department of Biomedical Engineering and Sciences, Universidad de Navarra, San Sebastián, SpainBioinformatics Group, CEIT, Water and Health Division, Universidad de Navarra, San Sebastián, SpainUnitat Mixta d’Investigació en Genòmica i Salut, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana-Salud Pública/Instituto de Biología Integrativa de Sistemas, Universitat de València, Valencia, SpainDepartment of Biological and Chemical Sciences, The University of the West Indies, Cave Hill, BarbadosUnitat Mixta d’Investigació en Genòmica i Salut, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana-Salud Pública/Instituto de Biología Integrativa de Sistemas, Universitat de València, Valencia, SpainCIBER en Epidemiología y Salud Pública, Madrid, SpainDepartamento de Nutrición y Bromatología, Instituto de Nutrición y Tecnología de los Alimentos, Centro de Investigación Biomédica, Universidad de Granada, Granada, SpainInstituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Granada, SpainBioinformatics Group, TECNUN School of Engineering, Department of Biomedical Engineering and Sciences, Universidad de Navarra, San Sebastián, SpainBioinformatics Group, CEIT, Water and Health Division, Universidad de Navarra, San Sebastián, SpainPredicting the metabolic behavior of the human gut microbiota in different contexts is one of the most promising areas of constraint-based modeling. Recently, we presented a supra-organismal approach to build context-specific metabolic networks of bacterial communities using functional and taxonomic assignments of meta-omics data. In this work, this algorithm is applied to elucidate the metabolic changes induced over the first year after birth in the gut microbiota of a cohort of Spanish infants. We used metagenomics data of fecal samples and nutritional data of 13 infants at five time points. The resulting networks for each time point were analyzed, finding significant alterations once solid food is introduced in the diet. Our work shows that solid food leads to a different pattern of output metabolites that can be potentially released from the gut microbiota to the host. Experimental validation is presented for ferulate, a neuroprotective metabolite involved in the gut-brain axis.https://www.frontiersin.org/article/10.3389/fmicb.2019.00848/fullpersonalized nutritionmetabolic networkshuman gut microbiomemetagenomicsmetabolomics |
| spellingShingle | Alvaro Fuertes Alvaro Fuertes Sergio Pérez-Burillo Iñigo Apaolaza Iñigo Apaolaza Yvonne Vallès Yvonne Vallès M. Pilar Francino M. Pilar Francino José Ángel Rufián-Henares José Ángel Rufián-Henares Francisco J. Planes Francisco J. Planes Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth Frontiers in Microbiology personalized nutrition metabolic networks human gut microbiome metagenomics metabolomics |
| title | Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth |
| title_full | Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth |
| title_fullStr | Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth |
| title_full_unstemmed | Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth |
| title_short | Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth |
| title_sort | adaptation of the human gut microbiota metabolic network during the first year after birth |
| topic | personalized nutrition metabolic networks human gut microbiome metagenomics metabolomics |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.00848/full |
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