JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss

JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss

Abstract Background Amplified inflammation is important for the progression of Parkinson’s disease (PD). However, how this enhanced inflammation is regulated remains largely unknown. Deletion of DICER leads to progressive dopamine neuronal loss and induces gliosis. We hypothesized that the homeostas...

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Bibliographic Details
Main Authors: Qing Wang, Qian He, Yifei Chen, Wei Shao, Chao Yuan, Yizheng Wang
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Neuroinflammation
Subjects:
DICER
Microglia
Inflammation
Degradation
Phosphorylation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1218-1

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http://link.springer.com/article/10.1186/s12974-018-1218-1

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