Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis)
The efficacy of Felpreva® (Vetoquinol), a new spot-on application containing the novel acaricide and insecticide tigolaner in combination with emodepside and praziquantel, was evaluated in cats artificially infested with ear mites (Otodectes cynotis). A total of three pivotal dose confirmation studi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Parasitology and Vector-Borne Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667114X23000195 |
| _version_ | 1827395233677049856 |
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| author | Katrin Blazejak Alta Viljoen Reinier Zwiegers Roland Klopper Hannah Ringeisen Gabriele Petry David R. Young Douglas Shane Jennifer Spruill Ronald K. Tessman Terry Settje Tanja N. Knoppe Norbert Mencke |
| author_facet | Katrin Blazejak Alta Viljoen Reinier Zwiegers Roland Klopper Hannah Ringeisen Gabriele Petry David R. Young Douglas Shane Jennifer Spruill Ronald K. Tessman Terry Settje Tanja N. Knoppe Norbert Mencke |
| author_sort | Katrin Blazejak |
| collection | DOAJ |
| description | The efficacy of Felpreva® (Vetoquinol), a new spot-on application containing the novel acaricide and insecticide tigolaner in combination with emodepside and praziquantel, was evaluated in cats artificially infested with ear mites (Otodectes cynotis). A total of three pivotal dose confirmation studies were conducted, two of them designed as non-interference studies. Cats were artificially infested with O. cynotis mites and randomly allocated into groups of 8 cats based on pre-treatment mite counts. Cats were treated once on Day 0, either with Felpreva® (14.5 mg/kg tigolaner, 3 mg/kg emodepside and 12 mg/kg praziquantel) or with placebo. Studies with a non-interference design included two additional groups of cats, treated with Profender® spot-on solution (Vetoquinol) (3 mg/kg emodepside and 12 mg/kg praziquantel) and tigolaner as a mono product (14.5 mg/kg tigolaner). Efficacy was evaluated on Day 28/Day 30 based on total live mite counts after ear flushing. Efficacy was claimed when: (i) at least six control cats per group were adequately infested with mites; (ii) calculated efficacy was ≥ 90% based on geometric mean mite counts; and (iii) the difference in mite counts between Felpreva®-treated cats and control cats was statistically significant (P ≤ 0.05). In two of the three studies, Felpreva®-treated cats were mite-free (100% efficacy) on Day 28/Day 30 and almost full efficacy (99.6%) was seen in the third study. The difference in mite counts between Felpreva®-treated cats and control cats was significant (P < 0.0001) in all three studies. All control cats were adequately infested in all three studies. The efficacy of Felpreva® against ear mite (Otodectes cynotis) infection in cats was confirmed. |
| first_indexed | 2024-03-08T18:30:06Z |
| format | Article |
| id | doaj.art-ce056d1761144b4e9d95ccaa194a39a0 |
| institution | Directory Open Access Journal |
| issn | 2667-114X |
| language | English |
| last_indexed | 2024-03-08T18:30:06Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Parasitology and Vector-Borne Diseases |
| spelling | doaj.art-ce056d1761144b4e9d95ccaa194a39a02023-12-30T04:45:16ZengElsevierCurrent Research in Parasitology and Vector-Borne Diseases2667-114X2023-01-014100131Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis)Katrin Blazejak0Alta Viljoen1Reinier Zwiegers2Roland Klopper3Hannah Ringeisen4Gabriele Petry5David R. Young6Douglas Shane7Jennifer Spruill8Ronald K. Tessman9Terry Settje10Tanja N. Knoppe11Norbert Mencke12Vetoquinol S.A., 37 Rue de la Victoire, 75009 Paris, France; Corresponding author.Clinvet International (Pty) Ltd, PO Box 11186, 9321 Universitas, South AfricaClinvet International (Pty) Ltd, PO Box 11186, 9321 Universitas, South AfricaClindata International (Pty) Ltd, PO Box 11186, 9321 Universitas, South AfricaElanco Animal Health Company, Alfred Nobel Str. 50, 40789 Monheim, GermanyElanco Animal Health Company, Alfred Nobel Str. 50, 40789 Monheim, GermanyYoung Veterinary Research Services, 3000 Spengler Way, Turlock, CA 95380, USAYoung Veterinary Research Services, 3000 Spengler Way, Turlock, CA 95380, USAYoung Veterinary Research Services, 3000 Spengler Way, Turlock, CA 95380, USAElanco Animal Health, 2500 Innovation Way, Greenfield, IN 46140, USAElanco Animal Health, 2500 Innovation Way, Greenfield, IN 46140, USAVet Advice, Dornstücken 25, 22607 Hamburg, GermanyVetoquinol S.A., 37 Rue de la Victoire, 75009 Paris, France; Corresponding author.The efficacy of Felpreva® (Vetoquinol), a new spot-on application containing the novel acaricide and insecticide tigolaner in combination with emodepside and praziquantel, was evaluated in cats artificially infested with ear mites (Otodectes cynotis). A total of three pivotal dose confirmation studies were conducted, two of them designed as non-interference studies. Cats were artificially infested with O. cynotis mites and randomly allocated into groups of 8 cats based on pre-treatment mite counts. Cats were treated once on Day 0, either with Felpreva® (14.5 mg/kg tigolaner, 3 mg/kg emodepside and 12 mg/kg praziquantel) or with placebo. Studies with a non-interference design included two additional groups of cats, treated with Profender® spot-on solution (Vetoquinol) (3 mg/kg emodepside and 12 mg/kg praziquantel) and tigolaner as a mono product (14.5 mg/kg tigolaner). Efficacy was evaluated on Day 28/Day 30 based on total live mite counts after ear flushing. Efficacy was claimed when: (i) at least six control cats per group were adequately infested with mites; (ii) calculated efficacy was ≥ 90% based on geometric mean mite counts; and (iii) the difference in mite counts between Felpreva®-treated cats and control cats was statistically significant (P ≤ 0.05). In two of the three studies, Felpreva®-treated cats were mite-free (100% efficacy) on Day 28/Day 30 and almost full efficacy (99.6%) was seen in the third study. The difference in mite counts between Felpreva®-treated cats and control cats was significant (P < 0.0001) in all three studies. All control cats were adequately infested in all three studies. The efficacy of Felpreva® against ear mite (Otodectes cynotis) infection in cats was confirmed.http://www.sciencedirect.com/science/article/pii/S2667114X23000195TigolanerFelpreva®Ear miteOtodectes cynotisCatOtoacariosis |
| spellingShingle | Katrin Blazejak Alta Viljoen Reinier Zwiegers Roland Klopper Hannah Ringeisen Gabriele Petry David R. Young Douglas Shane Jennifer Spruill Ronald K. Tessman Terry Settje Tanja N. Knoppe Norbert Mencke Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis) Current Research in Parasitology and Vector-Borne Diseases Tigolaner Felpreva® Ear mite Otodectes cynotis Cat Otoacariosis |
| title | Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis) |
| title_full | Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis) |
| title_fullStr | Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis) |
| title_full_unstemmed | Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis) |
| title_short | Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis) |
| title_sort | efficacy of felpreva r a new spot on formulation containing tigolaner emodepside and praziquantel applied as a single application to cats artificially infested with ear mites otodectes cynotis |
| topic | Tigolaner Felpreva® Ear mite Otodectes cynotis Cat Otoacariosis |
| url | http://www.sciencedirect.com/science/article/pii/S2667114X23000195 |
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