First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica.

First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica.

<h4>Objective</h4>To evaluate the safety, tolerability, and pharmacokinetics of single doses of BG00010 (neublastin, artemin, enovin) in subjects with unilateral sciatica.<h4>Methods</h4>This was a single-center, blinded, placebo-controlled, randomized Phase 1 sequential-coho...

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Bibliographic Details
Main Authors: Paul E Rolan, Gilmore O'Neill, Eve Versage, Jitesh Rana, Yongqiang Tang, Gerald Galluppi, Ernesto Aycardi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0125034

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