Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial
The cluster of metabolic disorders includes obesity, dyslipidemia, hypertension, and glucose intolerance, increasing the risk of developing cardiovascular diseases and type 2 diabetes. Evolving proofs suggest an essential role of microbiota in human health and disease, including digestion, energy an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/7/1580 |
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| author | Chaiyavat Chaiyasut Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Suchanat Khongtan Nanticha Khampithum Subramanian Thangaleela Sartjin Peerajan Akkarach Bumrungpert Khontaros Chaiyasut Sasithorn Sirilun Phakkharawat Sittiprapaporn |
| author_facet | Chaiyavat Chaiyasut Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Suchanat Khongtan Nanticha Khampithum Subramanian Thangaleela Sartjin Peerajan Akkarach Bumrungpert Khontaros Chaiyasut Sasithorn Sirilun Phakkharawat Sittiprapaporn |
| author_sort | Chaiyavat Chaiyasut |
| collection | DOAJ |
| description | The cluster of metabolic disorders includes obesity, dyslipidemia, hypertension, and glucose intolerance, increasing the risk of developing cardiovascular diseases and type 2 diabetes. Evolving proofs suggest an essential role of microbiota in human health and disease, including digestion, energy and glucose metabolism, immunomodulation, and brain function. The frequency of overweight is increasing, and the main causes for this are highly processed foods and less active lifestyles. Research is underway to unravel the probable relationship between obesity and intestinal microbiota. Here, we propose a method to understand and elucidate the synergistic function of prebiotics and probiotics in treating obesity. The biomarkers of obesity, such as cholesterol, gut permeability, oxidative stress, bacterial toxins, cytokines, and short-chain fatty acids, were analyzed in Thai obese individuals after being supplemented with a synbiotic preparation containing <i>Lactobacillus paracasei</i>, <i>Bifidobacterium longum</i>, <i>Bifidobacterium breve</i>, inulin, and fructooligosaccharide. The results reveal that the supplementation of synbiotics significantly altered the obesity-associated biomarkers in an appositive way. Further studies are warranted to use synbiotics as an adjuvant therapy for the management of obesity-related health issues. |
| first_indexed | 2024-03-10T09:39:37Z |
| format | Article |
| id | doaj.art-ce09485df61043049704d930837524a0 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T09:39:37Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-ce09485df61043049704d930837524a02023-11-22T03:47:29ZengMDPI AGFoods2304-81582021-07-01107158010.3390/foods10071580Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical TrialChaiyavat Chaiyasut0Bhagavathi Sundaram Sivamaruthi1Periyanaina Kesika2Suchanat Khongtan3Nanticha Khampithum4Subramanian Thangaleela5Sartjin Peerajan6Akkarach Bumrungpert7Khontaros Chaiyasut8Sasithorn Sirilun9Phakkharawat Sittiprapaporn10Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandHealth Innovation Institute, Chiangmai 50200, ThailandMahidol Nutrition Society, Faculty of Public Health, Mahidol University, Bangkok 10400, ThailandInstitute of Research and Development, Chiang Mai Rajabhat University, Chiangmai 50300, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandNeuropsychological Research Laboratory, Department of Anti-Aging and Regenerative Science, School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University, Bangkok 11120, ThailandThe cluster of metabolic disorders includes obesity, dyslipidemia, hypertension, and glucose intolerance, increasing the risk of developing cardiovascular diseases and type 2 diabetes. Evolving proofs suggest an essential role of microbiota in human health and disease, including digestion, energy and glucose metabolism, immunomodulation, and brain function. The frequency of overweight is increasing, and the main causes for this are highly processed foods and less active lifestyles. Research is underway to unravel the probable relationship between obesity and intestinal microbiota. Here, we propose a method to understand and elucidate the synergistic function of prebiotics and probiotics in treating obesity. The biomarkers of obesity, such as cholesterol, gut permeability, oxidative stress, bacterial toxins, cytokines, and short-chain fatty acids, were analyzed in Thai obese individuals after being supplemented with a synbiotic preparation containing <i>Lactobacillus paracasei</i>, <i>Bifidobacterium longum</i>, <i>Bifidobacterium breve</i>, inulin, and fructooligosaccharide. The results reveal that the supplementation of synbiotics significantly altered the obesity-associated biomarkers in an appositive way. Further studies are warranted to use synbiotics as an adjuvant therapy for the management of obesity-related health issues.https://www.mdpi.com/2304-8158/10/7/1580obesitysynbioticsLactobacillusBifidobacteriuminulinfructooligosaccharide |
| spellingShingle | Chaiyavat Chaiyasut Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Suchanat Khongtan Nanticha Khampithum Subramanian Thangaleela Sartjin Peerajan Akkarach Bumrungpert Khontaros Chaiyasut Sasithorn Sirilun Phakkharawat Sittiprapaporn Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial Foods obesity synbiotics Lactobacillus Bifidobacterium inulin fructooligosaccharide |
| title | Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial |
| title_full | Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial |
| title_fullStr | Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial |
| title_full_unstemmed | Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial |
| title_short | Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial |
| title_sort | synbiotic supplementation improves obesity index and metabolic biomarkers in thai obese adults a randomized clinical trial |
| topic | obesity synbiotics Lactobacillus Bifidobacterium inulin fructooligosaccharide |
| url | https://www.mdpi.com/2304-8158/10/7/1580 |
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