Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers
Diabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15–25% of DM patients develop DFU at least once in their lifetime. The lack of effective wound dressings and targeted therapy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/10/441 |
| _version_ | 1827703874376433664 |
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| author | Chew Teng Tan Kun Liang Zong Heng Ngo Christabel Thembela Dube Chin Yan Lim |
| author_facet | Chew Teng Tan Kun Liang Zong Heng Ngo Christabel Thembela Dube Chin Yan Lim |
| author_sort | Chew Teng Tan |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15–25% of DM patients develop DFU at least once in their lifetime. The lack of effective wound dressings and targeted therapy for DFUs often results in prolonged hospitalization and amputations. As the incidence of DM is projected to rise, the demand for specialized DFU wound management will continue to increase. Hence, it is of great interest to improve and develop effective DFU-specific wound dressings and therapies. In the last decade, 3D bioprinting technology has made a great contribution to the healthcare sector, with the development of personalized prosthetics, implants, and bioengineered tissues. In this review, we discuss the challenges faced in DFU wound management and how 3D bioprinting technology can be applied to advance current treatment methods, such as biomanufacturing of composite 3D human skin substitutes for skin grafting and the development of DFU-appropriate wound dressings. Future co-development of 3D bioprinting technologies with novel treatment approaches to mitigate DFU-specific pathophysiological challenges will be key to limiting the healthcare burden associated with the increasing prevalence of DM. |
| first_indexed | 2024-03-10T15:26:57Z |
| format | Article |
| id | doaj.art-ce0c203cc88940b692fa6ba88e183d88 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T15:26:57Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ce0c203cc88940b692fa6ba88e183d882023-11-20T17:57:33ZengMDPI AGBiomedicines2227-90592020-10-0181044110.3390/biomedicines8100441Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot UlcersChew Teng Tan0Kun Liang1Zong Heng Ngo2Christabel Thembela Dube3Chin Yan Lim4Skin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore 138648, SingaporeSkin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore 138648, SingaporeSkin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore 138648, SingaporeSkin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore 138648, SingaporeSkin Research Institute of Singapore (SRIS), Agency for Science, Technology and Research (A*STAR), Singapore 138648, SingaporeDiabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15–25% of DM patients develop DFU at least once in their lifetime. The lack of effective wound dressings and targeted therapy for DFUs often results in prolonged hospitalization and amputations. As the incidence of DM is projected to rise, the demand for specialized DFU wound management will continue to increase. Hence, it is of great interest to improve and develop effective DFU-specific wound dressings and therapies. In the last decade, 3D bioprinting technology has made a great contribution to the healthcare sector, with the development of personalized prosthetics, implants, and bioengineered tissues. In this review, we discuss the challenges faced in DFU wound management and how 3D bioprinting technology can be applied to advance current treatment methods, such as biomanufacturing of composite 3D human skin substitutes for skin grafting and the development of DFU-appropriate wound dressings. Future co-development of 3D bioprinting technologies with novel treatment approaches to mitigate DFU-specific pathophysiological challenges will be key to limiting the healthcare burden associated with the increasing prevalence of DM.https://www.mdpi.com/2227-9059/8/10/4413D bioprintingdiabetic foot ulcerswound healing |
| spellingShingle | Chew Teng Tan Kun Liang Zong Heng Ngo Christabel Thembela Dube Chin Yan Lim Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers Biomedicines 3D bioprinting diabetic foot ulcers wound healing |
| title | Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers |
| title_full | Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers |
| title_fullStr | Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers |
| title_full_unstemmed | Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers |
| title_short | Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers |
| title_sort | application of 3d bioprinting technologies to the management and treatment of diabetic foot ulcers |
| topic | 3D bioprinting diabetic foot ulcers wound healing |
| url | https://www.mdpi.com/2227-9059/8/10/441 |
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