First outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark involving six Danish-born cases
Background: Denmark is a low-incidence country for tuberculosis (TB) and multidrug-resistant (MDR) TB at 5 and 0.05 cases per 100,000 population, respectively. Until 2018, the transmission of MDR-TB was nonexistent except for a few pairwise related family cases. In this study, we describe the first...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222000959 |
| _version_ | 1818289282977103872 |
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| author | Camilla Hiul Suppli Anders Norman Dorte Bek Folkvardsen Tina Nørregaard Gissel Ulla Møller Weinreich Anders Koch Christian Wejse Troels Lillebaek |
| author_facet | Camilla Hiul Suppli Anders Norman Dorte Bek Folkvardsen Tina Nørregaard Gissel Ulla Møller Weinreich Anders Koch Christian Wejse Troels Lillebaek |
| author_sort | Camilla Hiul Suppli |
| collection | DOAJ |
| description | Background: Denmark is a low-incidence country for tuberculosis (TB) and multidrug-resistant (MDR) TB at 5 and 0.05 cases per 100,000 population, respectively. Until 2018, the transmission of MDR-TB was nonexistent except for a few pairwise related family cases. In this study, we describe the first MDR-TB outbreak in Denmark. Methods: On the basis of genotyping of all Mycobacterium tuberculosis (Mtb) culture-positive cases in Denmark spanning 3 decades, 6 molecular- and epidemiologically linked Danish-born cases were identified as the first cluster of an MDR-TB in Denmark. The primary case was diagnosed posthumously in 2010 followed by 5 epidemiologically linked cases from 2018 to 2019. Results and conclusion: Through a combination of routine Mtb genotyping and clinical epidemiological surveillance data, we identified the first Danish MDR-TB outbreak spanning 10 years and were able to disclose the specific transmission pathways in detail, which helped guide the outbreak investigations. The occurrence of an MDR-TB outbreak in a resource-rich low TB incidence setting such as Denmark highlights the importance of a collaborative control system combining classic contact tracing; timely identification of drug-resistant TB through rapid diagnostics; and a close collaboration between clinicians and classical- and molecular epidemiologists for the benefit of TB control. |
| first_indexed | 2024-12-13T02:09:48Z |
| format | Article |
| id | doaj.art-ce0e0bfcb6ef4726bc21560bd592007e |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-13T02:09:48Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-ce0e0bfcb6ef4726bc21560bd592007e2022-12-22T00:03:03ZengElsevierInternational Journal of Infectious Diseases1201-97122022-04-01117258263First outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark involving six Danish-born casesCamilla Hiul Suppli0Anders Norman1Dorte Bek Folkvardsen2Tina Nørregaard Gissel3Ulla Møller Weinreich4Anders Koch5Christian Wejse6Troels Lillebaek7International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen, DenmarkInternational Reference Laboratory of Mycobacteriology, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen, DenmarkInternational Reference Laboratory of Mycobacteriology, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen, DenmarkDepartment of Internal Medicine, Region Hospital Viborg, Denmark, Heibergs Alle 4F, DK-8800, Viborg, DenmarkDepartment of Respiratory Diseases, Aalborg University Hospital, Aalborg, Denmark, Mølleparkvej 4, DK-9000, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark, Søndre Skovvej 15, DK-9000, Aalborg, DenmarkGlobal Health Section, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, DK-1353, Copenhagen, Denmark; Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen, Denmark; Department of Infectious Diseases, Rigshospitalet University Hospital, Blegdamsvej 9, DK-2100, Copenhagen, DenmarkGloHAU, Center for Global Health, Dept of Public Health, Aarhus University, Denmark, Bartholins Allé 2, DK-8000, Aarhus C, Denmark; Dept of Infectious Diseases, Institute for Clinical Medicine, Aarhus University Hospital, Denmark, Palle Juul-Jensens Boulevard 99, DK-8200, Aarhus N, DenmarkInternational Reference Laboratory of Mycobacteriology, Statens Serum Institut, Artillerivej 5, DK-2300, Copenhagen, Denmark; Global Health Section, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, DK-1353, Copenhagen, Denmark; Corresponding author: Professor Troels Lillebaek, International Reference Laboratory of Mycobacteriology, Statens Serum Institut, 5 Artillerivej, DK-2300 Copenhagen, Denmark.Background: Denmark is a low-incidence country for tuberculosis (TB) and multidrug-resistant (MDR) TB at 5 and 0.05 cases per 100,000 population, respectively. Until 2018, the transmission of MDR-TB was nonexistent except for a few pairwise related family cases. In this study, we describe the first MDR-TB outbreak in Denmark. Methods: On the basis of genotyping of all Mycobacterium tuberculosis (Mtb) culture-positive cases in Denmark spanning 3 decades, 6 molecular- and epidemiologically linked Danish-born cases were identified as the first cluster of an MDR-TB in Denmark. The primary case was diagnosed posthumously in 2010 followed by 5 epidemiologically linked cases from 2018 to 2019. Results and conclusion: Through a combination of routine Mtb genotyping and clinical epidemiological surveillance data, we identified the first Danish MDR-TB outbreak spanning 10 years and were able to disclose the specific transmission pathways in detail, which helped guide the outbreak investigations. The occurrence of an MDR-TB outbreak in a resource-rich low TB incidence setting such as Denmark highlights the importance of a collaborative control system combining classic contact tracing; timely identification of drug-resistant TB through rapid diagnostics; and a close collaboration between clinicians and classical- and molecular epidemiologists for the benefit of TB control.http://www.sciencedirect.com/science/article/pii/S1201971222000959TuberculosisTBMDR-TBwhole genome sequence WGScontact tracingDenmark |
| spellingShingle | Camilla Hiul Suppli Anders Norman Dorte Bek Folkvardsen Tina Nørregaard Gissel Ulla Møller Weinreich Anders Koch Christian Wejse Troels Lillebaek First outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark involving six Danish-born cases International Journal of Infectious Diseases Tuberculosis TB MDR-TB whole genome sequence WGS contact tracing Denmark |
| title | First outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark involving six Danish-born cases |
| title_full | First outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark involving six Danish-born cases |
| title_fullStr | First outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark involving six Danish-born cases |
| title_full_unstemmed | First outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark involving six Danish-born cases |
| title_short | First outbreak of multidrug-resistant tuberculosis (MDR-TB) in Denmark involving six Danish-born cases |
| title_sort | first outbreak of multidrug resistant tuberculosis mdr tb in denmark involving six danish born cases |
| topic | Tuberculosis TB MDR-TB whole genome sequence WGS contact tracing Denmark |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222000959 |
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