Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

Abstract JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated dexamphetamine-induced improvements of mood and (visuo)motor performance...

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Main Authors: Kasper Recourt, Peter de Boer, Peter van der Ark, Heike Benes, Joop M. A. van Gerven, Marc Ceusters, Luc van Nueten, Wayne C. Drevets, Anindya Bhatacharya, Michael Browning, Gabriel E. Jacobs
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02557-5

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