Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
Abstract RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editing, splicing, stabilization, translational efficiency, or epigenetic modifications...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-024-00556-y |
| _version_ | 1797273911925145600 |
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| author | Wan‑Jia Qin Jin-Jin Shi Ru-Yi Chen Chang-Yun Li Yan-Jun Liu Jian-Fei Lu Guan-Jun Yang Jia-Feng Cao Jiong Chen |
| author_facet | Wan‑Jia Qin Jin-Jin Shi Ru-Yi Chen Chang-Yun Li Yan-Jun Liu Jian-Fei Lu Guan-Jun Yang Jia-Feng Cao Jiong Chen |
| author_sort | Wan‑Jia Qin |
| collection | DOAJ |
| description | Abstract RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editing, splicing, stabilization, translational efficiency, or epigenetic modifications of their binding RNA partners, and thereby modulate various physiological and pathological processes. CUG-BP, Elav-like family 1 (CELF1) is a member of the CELF family of RBPs with high affinity to the GU-rich elements in mRNA, and thus exerting control over critical processes including mRNA splicing, translation, and decay. Mounting studies support that CELF1 is correlated with occurrence, genesis and development and represents a potential therapeutical target for these malignant diseases. Herein, we present the structure and function of CELF1, outline its role and regulatory mechanisms in varieties of homeostasis and diseases, summarize the identified CELF1 regulators and their structure–activity relationships, and prospect the current challenges and their solutions during studies on CELF1 functions and corresponding drug discovery, which will facilitate the establishment of a targeted regulatory network for CELF1 in diseases and advance CELF1 as a potential drug target for disease therapy. Graphical Abstract |
| first_indexed | 2024-03-07T14:50:54Z |
| format | Article |
| id | doaj.art-ce0f8edb99e04023a8bdef57509fbbbf |
| institution | Directory Open Access Journal |
| issn | 1689-1392 |
| language | English |
| last_indexed | 2024-03-07T14:50:54Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-ce0f8edb99e04023a8bdef57509fbbbf2024-03-05T19:44:18ZengBMCCellular & Molecular Biology Letters1689-13922024-03-0129112210.1186/s11658-024-00556-yCurriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic reviewWan‑Jia Qin0Jin-Jin Shi1Ru-Yi Chen2Chang-Yun Li3Yan-Jun Liu4Jian-Fei Lu5Guan-Jun Yang6Jia-Feng Cao7Jiong Chen8State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo UniversityState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo UniversityState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo UniversityState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo UniversityState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo UniversityState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo UniversityState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo UniversityState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo UniversityState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo UniversityAbstract RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editing, splicing, stabilization, translational efficiency, or epigenetic modifications of their binding RNA partners, and thereby modulate various physiological and pathological processes. CUG-BP, Elav-like family 1 (CELF1) is a member of the CELF family of RBPs with high affinity to the GU-rich elements in mRNA, and thus exerting control over critical processes including mRNA splicing, translation, and decay. Mounting studies support that CELF1 is correlated with occurrence, genesis and development and represents a potential therapeutical target for these malignant diseases. Herein, we present the structure and function of CELF1, outline its role and regulatory mechanisms in varieties of homeostasis and diseases, summarize the identified CELF1 regulators and their structure–activity relationships, and prospect the current challenges and their solutions during studies on CELF1 functions and corresponding drug discovery, which will facilitate the establishment of a targeted regulatory network for CELF1 in diseases and advance CELF1 as a potential drug target for disease therapy. Graphical Abstracthttps://doi.org/10.1186/s11658-024-00556-yCELF1RNA-binding proteinDiseasesCancer therapyInhibitor |
| spellingShingle | Wan‑Jia Qin Jin-Jin Shi Ru-Yi Chen Chang-Yun Li Yan-Jun Liu Jian-Fei Lu Guan-Jun Yang Jia-Feng Cao Jiong Chen Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review Cellular & Molecular Biology Letters CELF1 RNA-binding protein Diseases Cancer therapy Inhibitor |
| title | Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review |
| title_full | Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review |
| title_fullStr | Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review |
| title_full_unstemmed | Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review |
| title_short | Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review |
| title_sort | curriculum vitae of cug binding protein 1 celf1 in homeostasis and diseases a systematic review |
| topic | CELF1 RNA-binding protein Diseases Cancer therapy Inhibitor |
| url | https://doi.org/10.1186/s11658-024-00556-y |
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