The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort study
Abstract Background Both nonthyroidal illness syndrome and renal dysfunction are associated with increased mortality risk in acute myocardial infarction (AMI). However, it is unclear whether combined NTIS and renal dysfunction further increase mortality risk. Therefore, our aim is to investigate whe...
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-019-1027-1 |
| _version_ | 1818313537445953536 |
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| author | Jun-Wei Wang Ying Ren Zhi-Gang Lu Jing Gao Cui-Chun Zhao Lian-Xi Li Meng Wei |
| author_facet | Jun-Wei Wang Ying Ren Zhi-Gang Lu Jing Gao Cui-Chun Zhao Lian-Xi Li Meng Wei |
| author_sort | Jun-Wei Wang |
| collection | DOAJ |
| description | Abstract Background Both nonthyroidal illness syndrome and renal dysfunction are associated with increased mortality risk in acute myocardial infarction (AMI). However, it is unclear whether combined NTIS and renal dysfunction further increase mortality risk. Therefore, our aim is to investigate whether combined NTIS and renal dysfunction further increases mortality risk in patients with acute myocardial infarction (AMI). Methods A total of 1295 inpatients with AMI were divided into normal group (n = 692), NTIS group (n = 139), renal dysfunction group (n = 304), and combined NTIS and renal dysfunction group (n = 160). Heart function, in-hospital, all-cause and cardiovascular mortality were compared among the four groups. Results After adjustment for age and sex, left ventricular ejection fraction was significantly lower in the combined group (48 ± 11%) than in the NTIS group (52 ± 10%, P = 0.017), the renal dysfunction group (52 ± 10%, P = 0.001) and the normal group (56 ± 8%, P < 0.001). After controlling for confounding factors, compared with the normal group, the NTIS and the renal dysfunction group represented higher risks of in-hospital mortality (OR: 3.643, P = 0.028; OR:3.135, P = 0.042, respectively), all-cause mortality (HR: 2.138, P = 0.007; HR: 2.050, P = 0.003, respectively), and cardiovascular mortality (HR:2.134, P = 0.042; HR:2.237, P = 0.010, respectively). Compared to those in the NTIS and the renal dysfunction group, the patients in the combined group showed a further increased risk for in-hospital mortality (OR:2.916, P = 0.039; OR:2.487, P = 0.036, respectively), all-cause mortality (HR: 1.939, P = 0.015; HR: 2.020, P = 0.002, respectively) and cardiovascular mortality (HR:2.420, P = 0.010; HR:2.303, P = 0.002, respectively). Conclusions Both NTIS and renal dysfunction increase short-term in-hospital mortality, and long-term all-cause and cardiovascular mortality risk in patients with AMI. Furthermore, the coexistence of NTIS and renal dysfunction presents further increased mortality risk in AMI patients. |
| first_indexed | 2024-12-13T08:35:19Z |
| format | Article |
| id | doaj.art-ce103724166d4a549770ae9914ccb5ef |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-13T08:35:19Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-ce103724166d4a549770ae9914ccb5ef2022-12-21T23:53:39ZengBMCBMC Cardiovascular Disorders1471-22612019-03-0119111010.1186/s12872-019-1027-1The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort studyJun-Wei Wang0Ying Ren1Zhi-Gang Lu2Jing Gao3Cui-Chun Zhao4Lian-Xi Li5Meng Wei6Department of VIP, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of VIP, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of VIP, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of VIP, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic DiseaseDepartment of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalAbstract Background Both nonthyroidal illness syndrome and renal dysfunction are associated with increased mortality risk in acute myocardial infarction (AMI). However, it is unclear whether combined NTIS and renal dysfunction further increase mortality risk. Therefore, our aim is to investigate whether combined NTIS and renal dysfunction further increases mortality risk in patients with acute myocardial infarction (AMI). Methods A total of 1295 inpatients with AMI were divided into normal group (n = 692), NTIS group (n = 139), renal dysfunction group (n = 304), and combined NTIS and renal dysfunction group (n = 160). Heart function, in-hospital, all-cause and cardiovascular mortality were compared among the four groups. Results After adjustment for age and sex, left ventricular ejection fraction was significantly lower in the combined group (48 ± 11%) than in the NTIS group (52 ± 10%, P = 0.017), the renal dysfunction group (52 ± 10%, P = 0.001) and the normal group (56 ± 8%, P < 0.001). After controlling for confounding factors, compared with the normal group, the NTIS and the renal dysfunction group represented higher risks of in-hospital mortality (OR: 3.643, P = 0.028; OR:3.135, P = 0.042, respectively), all-cause mortality (HR: 2.138, P = 0.007; HR: 2.050, P = 0.003, respectively), and cardiovascular mortality (HR:2.134, P = 0.042; HR:2.237, P = 0.010, respectively). Compared to those in the NTIS and the renal dysfunction group, the patients in the combined group showed a further increased risk for in-hospital mortality (OR:2.916, P = 0.039; OR:2.487, P = 0.036, respectively), all-cause mortality (HR: 1.939, P = 0.015; HR: 2.020, P = 0.002, respectively) and cardiovascular mortality (HR:2.420, P = 0.010; HR:2.303, P = 0.002, respectively). Conclusions Both NTIS and renal dysfunction increase short-term in-hospital mortality, and long-term all-cause and cardiovascular mortality risk in patients with AMI. Furthermore, the coexistence of NTIS and renal dysfunction presents further increased mortality risk in AMI patients.http://link.springer.com/article/10.1186/s12872-019-1027-1Nonthyroidal illness syndromeRenal insufficiencyAcute myocardial infarctionCardio-renal-nonthyroidal illness syndrome |
| spellingShingle | Jun-Wei Wang Ying Ren Zhi-Gang Lu Jing Gao Cui-Chun Zhao Lian-Xi Li Meng Wei The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort study BMC Cardiovascular Disorders Nonthyroidal illness syndrome Renal insufficiency Acute myocardial infarction Cardio-renal-nonthyroidal illness syndrome |
| title | The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort study |
| title_full | The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort study |
| title_fullStr | The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort study |
| title_full_unstemmed | The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort study |
| title_short | The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort study |
| title_sort | combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction a prospective cohort study |
| topic | Nonthyroidal illness syndrome Renal insufficiency Acute myocardial infarction Cardio-renal-nonthyroidal illness syndrome |
| url | http://link.springer.com/article/10.1186/s12872-019-1027-1 |
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