Impact of metabolic syndrome on the long-term prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after hepatectomy
Background & aimsThe long-term prognosis of patients with metabolic syndrome (MS) and hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) after radical hepatectomy remains unclear. The purpose of this study was to elucidate the effect of MS on long-term survival for patients with HB...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1042869/full |
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| author | Kang-Jun Zhang Kang-Jun Zhang Tai-Wei Ye Wen-Feng Lu Fei-Qi Xu Fei-Qi Xu Ya-Ming Xie Dong-Dong Wang Zun-Qiang Xiao Si-Yu Liu Wei-Feng Yao Jian Cheng Guo-Liang Shen Jun-Wei Liu Cheng-Wu Zhang Dong-Sheng Huang Dong-Sheng Huang Dong-Sheng Huang Lei Liang Lei Liang |
| author_facet | Kang-Jun Zhang Kang-Jun Zhang Tai-Wei Ye Wen-Feng Lu Fei-Qi Xu Fei-Qi Xu Ya-Ming Xie Dong-Dong Wang Zun-Qiang Xiao Si-Yu Liu Wei-Feng Yao Jian Cheng Guo-Liang Shen Jun-Wei Liu Cheng-Wu Zhang Dong-Sheng Huang Dong-Sheng Huang Dong-Sheng Huang Lei Liang Lei Liang |
| author_sort | Kang-Jun Zhang |
| collection | DOAJ |
| description | Background & aimsThe long-term prognosis of patients with metabolic syndrome (MS) and hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) after radical hepatectomy remains unclear. The purpose of this study was to elucidate the effect of MS on long-term survival for patients with HBV-related HCC after hepatectomy.MethodsPatients with HBV-HCC after hepatectomy were included. Patients were stratified into MS-HBV-HCC and HBV-HCC groups. Clinical features and surgical outcomes were compared between the two groups, and COX regression analysis was used to determine independent risk factors associated with overall survival (OS) and recurrence-free survival (RFS).Result389 patients (MS-HBV-HCC group: n=50, HBV-HCC group: n=339) were enrolled for further analysis. Baseline characteristics showed that patients with MS-HBV-HCC were associated with a high rate of elderly patients, ASA score, and co-morbid illness, but a lower rate of anatomy hepatectomy. There were no significant differences in perioperative complications. After excluding patients who relapsed or died within 90 days after surgery, multivariate Cox regression analysis showed MS was an independent risk factor of OS (HR 1.68, 95% CI 1.05-2.70, P = 0.032) and RFS (HR 1.78, 95% CI 1.24-2.57, P = 0.002).ConclusionMS is an independent risk factor for poor OS and RFS in HBV-infected HCC patients after radical hepatectomy. This suggests that we need to strengthen postoperative follow-up of the relevant population and encourage patients to develop a healthy lifestyle. |
| first_indexed | 2024-04-11T07:22:30Z |
| format | Article |
| id | doaj.art-ce124981c2d042cfad1f07be679efb1c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T07:22:30Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ce124981c2d042cfad1f07be679efb1c2022-12-22T04:37:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.10428691042869Impact of metabolic syndrome on the long-term prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after hepatectomyKang-Jun Zhang0Kang-Jun Zhang1Tai-Wei Ye2Wen-Feng Lu3Fei-Qi Xu4Fei-Qi Xu5Ya-Ming Xie6Dong-Dong Wang7Zun-Qiang Xiao8Si-Yu Liu9Wei-Feng Yao10Jian Cheng11Guo-Liang Shen12Jun-Wei Liu13Cheng-Wu Zhang14Dong-Sheng Huang15Dong-Sheng Huang16Dong-Sheng Huang17Lei Liang18Lei Liang19General Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaDepartment of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Navy Medical University), Shanghai, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaDepartment of Medical, Lishui Municipal Central Hospital, Lishui, Zhejiang, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, ChinaDepartment of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaGeneral Surgery, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, ChinaKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, ChinaBackground & aimsThe long-term prognosis of patients with metabolic syndrome (MS) and hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) after radical hepatectomy remains unclear. The purpose of this study was to elucidate the effect of MS on long-term survival for patients with HBV-related HCC after hepatectomy.MethodsPatients with HBV-HCC after hepatectomy were included. Patients were stratified into MS-HBV-HCC and HBV-HCC groups. Clinical features and surgical outcomes were compared between the two groups, and COX regression analysis was used to determine independent risk factors associated with overall survival (OS) and recurrence-free survival (RFS).Result389 patients (MS-HBV-HCC group: n=50, HBV-HCC group: n=339) were enrolled for further analysis. Baseline characteristics showed that patients with MS-HBV-HCC were associated with a high rate of elderly patients, ASA score, and co-morbid illness, but a lower rate of anatomy hepatectomy. There were no significant differences in perioperative complications. After excluding patients who relapsed or died within 90 days after surgery, multivariate Cox regression analysis showed MS was an independent risk factor of OS (HR 1.68, 95% CI 1.05-2.70, P = 0.032) and RFS (HR 1.78, 95% CI 1.24-2.57, P = 0.002).ConclusionMS is an independent risk factor for poor OS and RFS in HBV-infected HCC patients after radical hepatectomy. This suggests that we need to strengthen postoperative follow-up of the relevant population and encourage patients to develop a healthy lifestyle.https://www.frontiersin.org/articles/10.3389/fonc.2022.1042869/fullmetabolic syndromehepatitis virus Bhepatocellular carcinomahepatectomysurvival |
| spellingShingle | Kang-Jun Zhang Kang-Jun Zhang Tai-Wei Ye Wen-Feng Lu Fei-Qi Xu Fei-Qi Xu Ya-Ming Xie Dong-Dong Wang Zun-Qiang Xiao Si-Yu Liu Wei-Feng Yao Jian Cheng Guo-Liang Shen Jun-Wei Liu Cheng-Wu Zhang Dong-Sheng Huang Dong-Sheng Huang Dong-Sheng Huang Lei Liang Lei Liang Impact of metabolic syndrome on the long-term prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after hepatectomy Frontiers in Oncology metabolic syndrome hepatitis virus B hepatocellular carcinoma hepatectomy survival |
| title | Impact of metabolic syndrome on the long-term prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after hepatectomy |
| title_full | Impact of metabolic syndrome on the long-term prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after hepatectomy |
| title_fullStr | Impact of metabolic syndrome on the long-term prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after hepatectomy |
| title_full_unstemmed | Impact of metabolic syndrome on the long-term prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after hepatectomy |
| title_short | Impact of metabolic syndrome on the long-term prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after hepatectomy |
| title_sort | impact of metabolic syndrome on the long term prognosis of patients with hepatitis b virus related hepatocellular carcinoma after hepatectomy |
| topic | metabolic syndrome hepatitis virus B hepatocellular carcinoma hepatectomy survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1042869/full |
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