Endless Forms: Within-Host Variation in the Structure of the West Nile Virus RNA Genome during Serial Passage in Bird Hosts

Endless Forms: Within-Host Variation in the Structure of the West Nile Virus RNA Genome during Serial Passage in Bird Hosts

ABSTRACT RNA viruses are infamous for their high rates of mutation, which produce swarms of genetic variants within individual hosts. To date, analyses of intrahost genetic diversity have focused on the primary genome sequence. However, virus phenotypes are shaped not only by primary sequence but al...

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Bibliographic Details
Main Authors: Stacey L. P. Scroggs, Nathan D. Grubaugh, Johnny A. Sena, Anitha Sundararajan, Faye D. Schilkey, Darci R. Smith, Gregory D. Ebel, Kathryn A. Hanley
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mSphere
Subjects:
RNA virus
West Nile virus
evolution
genetic diversity
natural selection
quasispecies
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00291-19

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