Autophagy is a critical regulator of memory CD8+ T cell formation

Autophagy is a critical regulator of memory CD8+ T cell formation

During infection, CD8+ T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that CD8+ T cell memory formation becomes defective in old age, the cellular mechanism is largely unknown. Autophagy is a major cellular lysosomal d...

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Bibliographic Details
Main Authors: Daniel J Puleston, Hanlin Zhang, Timothy J Powell, Elina Lipina, Stuart Sims, Isabel Panse, Alexander S Watson, Vincenzo Cerundolo, Alain RM Townsend, Paul Klenerman, Anna Katharina Simon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-11-01
Series:eLife
Subjects:
autophagy
memory T cell
vaccination
ageing
spermidine
influenza
Online Access:https://elifesciences.org/articles/03706

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