Nicotinic Receptors: Role in Addiction and other Disorders of the Brain
Nicotine, the addictive component of cigarette smoke has profound effects on the brain. Activation of its receptors by nicotine has complex consequences for network activity throughout the brain, potentially contributing to the addictive property of the drug. Nicotinic receptors have been implicated...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2008-01-01
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| Series: | Substance Abuse: Research and Treatment |
| Subjects: | |
| Online Access: | http://www.la-press.com/nicotinic-receptors-role-in-addiction-and-other-disorders-of-the--a1144 |
| _version_ | 1818885749270904832 |
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| author | Geeta Sharma Sukumar Vijayaraghavan |
| author_facet | Geeta Sharma Sukumar Vijayaraghavan |
| author_sort | Geeta Sharma |
| collection | DOAJ |
| description | Nicotine, the addictive component of cigarette smoke has profound effects on the brain. Activation of its receptors by nicotine has complex consequences for network activity throughout the brain, potentially contributing to the addictive property of the drug. Nicotinic receptors have been implicated in psychiatric illnesses like schizophrenia and are also neuroprotective, potentially beneficial for neurodegenerative diseases. These effects of nicotine serve to emphasize the multifarious roles the drug, acting through multiple nicotinic acetylcholine receptor subtypes. The findings also remind us of the complexity of signaling mechanisms and stress the risks of unintended consequences of drugs designed to combat nicotine addiction. |
| first_indexed | 2024-12-19T16:10:23Z |
| format | Article |
| id | doaj.art-ce14024d638b46df817f789696a6eb22 |
| institution | Directory Open Access Journal |
| issn | 1178-2218 |
| language | English |
| last_indexed | 2024-12-19T16:10:23Z |
| publishDate | 2008-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Substance Abuse: Research and Treatment |
| spelling | doaj.art-ce14024d638b46df817f789696a6eb222022-12-21T20:14:46ZengSAGE PublishingSubstance Abuse: Research and Treatment1178-22182008-01-0118195Nicotinic Receptors: Role in Addiction and other Disorders of the BrainGeeta SharmaSukumar VijayaraghavanNicotine, the addictive component of cigarette smoke has profound effects on the brain. Activation of its receptors by nicotine has complex consequences for network activity throughout the brain, potentially contributing to the addictive property of the drug. Nicotinic receptors have been implicated in psychiatric illnesses like schizophrenia and are also neuroprotective, potentially beneficial for neurodegenerative diseases. These effects of nicotine serve to emphasize the multifarious roles the drug, acting through multiple nicotinic acetylcholine receptor subtypes. The findings also remind us of the complexity of signaling mechanisms and stress the risks of unintended consequences of drugs designed to combat nicotine addiction.http://www.la-press.com/nicotinic-receptors-role-in-addiction-and-other-disorders-of-the--a1144Nicotinedrug abusenetworkhedonic homeostasisCalcium |
| spellingShingle | Geeta Sharma Sukumar Vijayaraghavan Nicotinic Receptors: Role in Addiction and other Disorders of the Brain Substance Abuse: Research and Treatment Nicotine drug abuse network hedonic homeostasis Calcium |
| title | Nicotinic Receptors: Role in Addiction and other Disorders of the Brain |
| title_full | Nicotinic Receptors: Role in Addiction and other Disorders of the Brain |
| title_fullStr | Nicotinic Receptors: Role in Addiction and other Disorders of the Brain |
| title_full_unstemmed | Nicotinic Receptors: Role in Addiction and other Disorders of the Brain |
| title_short | Nicotinic Receptors: Role in Addiction and other Disorders of the Brain |
| title_sort | nicotinic receptors role in addiction and other disorders of the brain |
| topic | Nicotine drug abuse network hedonic homeostasis Calcium |
| url | http://www.la-press.com/nicotinic-receptors-role-in-addiction-and-other-disorders-of-the--a1144 |
| work_keys_str_mv | AT geetasharma nicotinicreceptorsroleinaddictionandotherdisordersofthebrain AT sukumarvijayaraghavan nicotinicreceptorsroleinaddictionandotherdisordersofthebrain |