To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections

CD8 T cells coordinate immune defenses against viral infections of the central nervous system (CNS). Virus-specific CD8 T cells infiltrate the CNS and differentiate into brain-resident memory CD8 T cells (CD8 bT<sub>RM</sub>). CD8 bT<sub>RM</sub> are characterized by a lack o...

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Main Authors: Taryn E. Mockus, Heather M. Ren, Shwetank, Aron E. Lukacher
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/11/9/842
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author Taryn E. Mockus
Heather M. Ren
Shwetank
Aron E. Lukacher
author_facet Taryn E. Mockus
Heather M. Ren
Shwetank
Aron E. Lukacher
author_sort Taryn E. Mockus
collection DOAJ
description CD8 T cells coordinate immune defenses against viral infections of the central nervous system (CNS). Virus-specific CD8 T cells infiltrate the CNS and differentiate into brain-resident memory CD8 T cells (CD8 bT<sub>RM</sub>). CD8 bT<sub>RM</sub> are characterized by a lack of recirculation and expression of phenotypes and transcriptomes distinct from other CD8 T cell memory subsets. CD8 bT<sub>RM</sub> have been shown to provide durable, autonomous protection against viral reinfection and the resurgence of latent viral infections. CD8 T cells have also been implicated in the development of neural damage following viral infection, which demonstrates that the infiltration of CD8 T cells into the brain can also be pathogenic. In this review, we will explore the residency and maintenance requirements for CD8 bT<sub>RM</sub> and discuss their roles in controlling viral infections of the brain.
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spelling doaj.art-ce15205c60b4473da2f18fb3c3f5398c2022-12-21T22:55:50ZengMDPI AGViruses1999-49152019-09-0111984210.3390/v11090842v11090842To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral InfectionsTaryn E. Mockus0Heather M. Ren1Shwetank2Aron E. Lukacher3Department of Neurology, Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USABiocon Bristol-Myers Squib Research and Development Center, Biocon Park, Bengaluru 560099, IndiaDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USACD8 T cells coordinate immune defenses against viral infections of the central nervous system (CNS). Virus-specific CD8 T cells infiltrate the CNS and differentiate into brain-resident memory CD8 T cells (CD8 bT<sub>RM</sub>). CD8 bT<sub>RM</sub> are characterized by a lack of recirculation and expression of phenotypes and transcriptomes distinct from other CD8 T cell memory subsets. CD8 bT<sub>RM</sub> have been shown to provide durable, autonomous protection against viral reinfection and the resurgence of latent viral infections. CD8 T cells have also been implicated in the development of neural damage following viral infection, which demonstrates that the infiltration of CD8 T cells into the brain can also be pathogenic. In this review, we will explore the residency and maintenance requirements for CD8 bT<sub>RM</sub> and discuss their roles in controlling viral infections of the brain.https://www.mdpi.com/1999-4915/11/9/842CD8 T cellsresident memory T cellsviral infectioncentral nervous system
spellingShingle Taryn E. Mockus
Heather M. Ren
Shwetank
Aron E. Lukacher
To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections
Viruses
CD8 T cells
resident memory T cells
viral infection
central nervous system
title To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections
title_full To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections
title_fullStr To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections
title_full_unstemmed To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections
title_short To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections
title_sort to go or stay the development benefit and detriment of tissue resident memory cd8 t cells during central nervous system viral infections
topic CD8 T cells
resident memory T cells
viral infection
central nervous system
url https://www.mdpi.com/1999-4915/11/9/842
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