To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections
CD8 T cells coordinate immune defenses against viral infections of the central nervous system (CNS). Virus-specific CD8 T cells infiltrate the CNS and differentiate into brain-resident memory CD8 T cells (CD8 bT<sub>RM</sub>). CD8 bT<sub>RM</sub> are characterized by a lack o...
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Format: | Article |
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MDPI AG
2019-09-01
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Series: | Viruses |
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Online Access: | https://www.mdpi.com/1999-4915/11/9/842 |
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author | Taryn E. Mockus Heather M. Ren Shwetank Aron E. Lukacher |
author_facet | Taryn E. Mockus Heather M. Ren Shwetank Aron E. Lukacher |
author_sort | Taryn E. Mockus |
collection | DOAJ |
description | CD8 T cells coordinate immune defenses against viral infections of the central nervous system (CNS). Virus-specific CD8 T cells infiltrate the CNS and differentiate into brain-resident memory CD8 T cells (CD8 bT<sub>RM</sub>). CD8 bT<sub>RM</sub> are characterized by a lack of recirculation and expression of phenotypes and transcriptomes distinct from other CD8 T cell memory subsets. CD8 bT<sub>RM</sub> have been shown to provide durable, autonomous protection against viral reinfection and the resurgence of latent viral infections. CD8 T cells have also been implicated in the development of neural damage following viral infection, which demonstrates that the infiltration of CD8 T cells into the brain can also be pathogenic. In this review, we will explore the residency and maintenance requirements for CD8 bT<sub>RM</sub> and discuss their roles in controlling viral infections of the brain. |
first_indexed | 2024-12-14T15:32:49Z |
format | Article |
id | doaj.art-ce15205c60b4473da2f18fb3c3f5398c |
institution | Directory Open Access Journal |
issn | 1999-4915 |
language | English |
last_indexed | 2024-12-14T15:32:49Z |
publishDate | 2019-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Viruses |
spelling | doaj.art-ce15205c60b4473da2f18fb3c3f5398c2022-12-21T22:55:50ZengMDPI AGViruses1999-49152019-09-0111984210.3390/v11090842v11090842To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral InfectionsTaryn E. Mockus0Heather M. Ren1Shwetank2Aron E. Lukacher3Department of Neurology, Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USABiocon Bristol-Myers Squib Research and Development Center, Biocon Park, Bengaluru 560099, IndiaDepartment of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USACD8 T cells coordinate immune defenses against viral infections of the central nervous system (CNS). Virus-specific CD8 T cells infiltrate the CNS and differentiate into brain-resident memory CD8 T cells (CD8 bT<sub>RM</sub>). CD8 bT<sub>RM</sub> are characterized by a lack of recirculation and expression of phenotypes and transcriptomes distinct from other CD8 T cell memory subsets. CD8 bT<sub>RM</sub> have been shown to provide durable, autonomous protection against viral reinfection and the resurgence of latent viral infections. CD8 T cells have also been implicated in the development of neural damage following viral infection, which demonstrates that the infiltration of CD8 T cells into the brain can also be pathogenic. In this review, we will explore the residency and maintenance requirements for CD8 bT<sub>RM</sub> and discuss their roles in controlling viral infections of the brain.https://www.mdpi.com/1999-4915/11/9/842CD8 T cellsresident memory T cellsviral infectioncentral nervous system |
spellingShingle | Taryn E. Mockus Heather M. Ren Shwetank Aron E. Lukacher To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections Viruses CD8 T cells resident memory T cells viral infection central nervous system |
title | To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections |
title_full | To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections |
title_fullStr | To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections |
title_full_unstemmed | To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections |
title_short | To Go or Stay: The Development, Benefit, and Detriment of Tissue-Resident Memory CD8 T Cells during Central Nervous System Viral Infections |
title_sort | to go or stay the development benefit and detriment of tissue resident memory cd8 t cells during central nervous system viral infections |
topic | CD8 T cells resident memory T cells viral infection central nervous system |
url | https://www.mdpi.com/1999-4915/11/9/842 |
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