Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study
Abstract Background Colorectal cancer is considered a potential causative agent of morbidity and death, making it a particularly dangerous malignancy. The current study aims to assess the efficacy of ferulic acid (FA) to attenuate the harmful side effect of 5-fluorouracil (5FU) in colon cancer tissu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-06-01
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| Series: | Journal of Basic and Applied Zoology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41936-022-00293-8 |
| _version_ | 1811241216500563968 |
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| author | Mohamed H. A. Gadelmawla Ahmed S. Alazzouni AbdelRazik H. Farag Mohamed S. Gabri Basma N. Hassan |
| author_facet | Mohamed H. A. Gadelmawla Ahmed S. Alazzouni AbdelRazik H. Farag Mohamed S. Gabri Basma N. Hassan |
| author_sort | Mohamed H. A. Gadelmawla |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer is considered a potential causative agent of morbidity and death, making it a particularly dangerous malignancy. The current study aims to assess the efficacy of ferulic acid (FA) to attenuate the harmful side effect of 5-fluorouracil (5FU) in colon cancer tissues induced by 1,2-dimethylhydrazine (DMH). Results Regarding the colon tissues of male Wistar-albino rats (Rattus norvegicus), combined FA and 5FU showed the approximately normal structure of mucosa. The treated groups showed a remarkable reduction in Ki67, Ck20, and an elevation in caspase-3 and P53. There was significant upregulation of P53 in both 5FU and combined FA–5FU groups (p < 0.001 and p < 0.00001, respectively). Conclusions The present results revealed a potential role of the combined therapy by 5FU and FA in the suppression of colon cancer induced by DMH by upregulation of apoptosis with the clear effect of FA in attenuating the side effects of 5FU on the normal cells. |
| first_indexed | 2024-04-12T13:32:19Z |
| format | Article |
| id | doaj.art-ce165a62b8d14d529f1974f99e6f61cb |
| institution | Directory Open Access Journal |
| issn | 2090-990X |
| language | English |
| last_indexed | 2024-04-12T13:32:19Z |
| publishDate | 2022-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Basic and Applied Zoology |
| spelling | doaj.art-ce165a62b8d14d529f1974f99e6f61cb2022-12-22T03:31:08ZengSpringerOpenJournal of Basic and Applied Zoology2090-990X2022-06-0183111110.1186/s41936-022-00293-8Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo studyMohamed H. A. Gadelmawla0Ahmed S. Alazzouni1AbdelRazik H. Farag2Mohamed S. Gabri3Basma N. Hassan4Histology Department, Faculty of Dentistry, Sinai UniversityZoology and Entomology Department, Faculty of Science, Helwan UniversityPathology Department, National Research CenterZoology and Entomology Department, Faculty of Science, Helwan UniversityZoology and Entomology Department, Faculty of Science, Helwan UniversityAbstract Background Colorectal cancer is considered a potential causative agent of morbidity and death, making it a particularly dangerous malignancy. The current study aims to assess the efficacy of ferulic acid (FA) to attenuate the harmful side effect of 5-fluorouracil (5FU) in colon cancer tissues induced by 1,2-dimethylhydrazine (DMH). Results Regarding the colon tissues of male Wistar-albino rats (Rattus norvegicus), combined FA and 5FU showed the approximately normal structure of mucosa. The treated groups showed a remarkable reduction in Ki67, Ck20, and an elevation in caspase-3 and P53. There was significant upregulation of P53 in both 5FU and combined FA–5FU groups (p < 0.001 and p < 0.00001, respectively). Conclusions The present results revealed a potential role of the combined therapy by 5FU and FA in the suppression of colon cancer induced by DMH by upregulation of apoptosis with the clear effect of FA in attenuating the side effects of 5FU on the normal cells.https://doi.org/10.1186/s41936-022-00293-8Ferulic acid5-FluorouracilColon cancer1,2-DimethylhydrazineCaspase-3P53 |
| spellingShingle | Mohamed H. A. Gadelmawla Ahmed S. Alazzouni AbdelRazik H. Farag Mohamed S. Gabri Basma N. Hassan Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study Journal of Basic and Applied Zoology Ferulic acid 5-Fluorouracil Colon cancer 1,2-Dimethylhydrazine Caspase-3 P53 |
| title | Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study |
| title_full | Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study |
| title_fullStr | Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study |
| title_full_unstemmed | Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study |
| title_short | Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study |
| title_sort | enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer docking and in vivo study |
| topic | Ferulic acid 5-Fluorouracil Colon cancer 1,2-Dimethylhydrazine Caspase-3 P53 |
| url | https://doi.org/10.1186/s41936-022-00293-8 |
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