Cyclitols: From Basic Understanding to Their Association with Neurodegeneration
One of the most common cyclitols found in eukaryotic cells—Myo-inositol (MI) and its derivatives play a key role in many cellular processes such as ion channel physiology, signal transduction, phosphate storage, cell wall formation, membrane biogenesis and osmoregulation. The aim of this paper is to...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/9/2029 |
| _version_ | 1797602055216431104 |
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| author | Maria Derkaczew Piotr Martyniuk Adam Osowski Joanna Wojtkiewicz |
| author_facet | Maria Derkaczew Piotr Martyniuk Adam Osowski Joanna Wojtkiewicz |
| author_sort | Maria Derkaczew |
| collection | DOAJ |
| description | One of the most common cyclitols found in eukaryotic cells—Myo-inositol (MI) and its derivatives play a key role in many cellular processes such as ion channel physiology, signal transduction, phosphate storage, cell wall formation, membrane biogenesis and osmoregulation. The aim of this paper is to characterize the possibility of neurodegenerative disorders treatment using MI and the research of other therapeutic methods linked to MI’s derivatives. Based on the reviewed literature the researchers focus on the most common neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Spinocerebellar ataxias, but there are also works describing other seldom encountered diseases. The use of MI, <span style="font-variant: small-caps;">d</span>-pinitol and other methods altering MI’s metabolism, although research on this topic has been conducted for years, still needs much closer examination. The dietary supplementation of MI shows a promising effect on the treatment of neurodegenerative disorders and can be of great help in alleviating the accompanying depressive symptoms. |
| first_indexed | 2024-03-11T04:11:34Z |
| format | Article |
| id | doaj.art-ce182e93a273433a86ec1cdd8da7af6d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T04:11:34Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ce182e93a273433a86ec1cdd8da7af6d2023-11-17T23:28:10ZengMDPI AGNutrients2072-66432023-04-01159202910.3390/nu15092029Cyclitols: From Basic Understanding to Their Association with NeurodegenerationMaria Derkaczew0Piotr Martyniuk1Adam Osowski2Joanna Wojtkiewicz3Department of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, PolandDepartment of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, PolandDepartment of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, PolandDepartment of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-082 Olsztyn, PolandOne of the most common cyclitols found in eukaryotic cells—Myo-inositol (MI) and its derivatives play a key role in many cellular processes such as ion channel physiology, signal transduction, phosphate storage, cell wall formation, membrane biogenesis and osmoregulation. The aim of this paper is to characterize the possibility of neurodegenerative disorders treatment using MI and the research of other therapeutic methods linked to MI’s derivatives. Based on the reviewed literature the researchers focus on the most common neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Spinocerebellar ataxias, but there are also works describing other seldom encountered diseases. The use of MI, <span style="font-variant: small-caps;">d</span>-pinitol and other methods altering MI’s metabolism, although research on this topic has been conducted for years, still needs much closer examination. The dietary supplementation of MI shows a promising effect on the treatment of neurodegenerative disorders and can be of great help in alleviating the accompanying depressive symptoms.https://www.mdpi.com/2072-6643/15/9/2029myo-inositol<span style="font-variant: small-caps">d</span>-pinitolinositol phosphatesneurodegenerative disordersAlzheimer’s diseaseParkinson’s disease |
| spellingShingle | Maria Derkaczew Piotr Martyniuk Adam Osowski Joanna Wojtkiewicz Cyclitols: From Basic Understanding to Their Association with Neurodegeneration Nutrients myo-inositol <span style="font-variant: small-caps">d</span>-pinitol inositol phosphates neurodegenerative disorders Alzheimer’s disease Parkinson’s disease |
| title | Cyclitols: From Basic Understanding to Their Association with Neurodegeneration |
| title_full | Cyclitols: From Basic Understanding to Their Association with Neurodegeneration |
| title_fullStr | Cyclitols: From Basic Understanding to Their Association with Neurodegeneration |
| title_full_unstemmed | Cyclitols: From Basic Understanding to Their Association with Neurodegeneration |
| title_short | Cyclitols: From Basic Understanding to Their Association with Neurodegeneration |
| title_sort | cyclitols from basic understanding to their association with neurodegeneration |
| topic | myo-inositol <span style="font-variant: small-caps">d</span>-pinitol inositol phosphates neurodegenerative disorders Alzheimer’s disease Parkinson’s disease |
| url | https://www.mdpi.com/2072-6643/15/9/2029 |
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