Post mortem mapping of connectional anatomy for the validation of diffusion MRI
Diffusion MRI (dMRI) is a unique tool for the study of brain circuitry, as it allows us to image both the macroscopic trajectories and the microstructural properties of axon bundles in vivo. The Human Connectome Project ushered in an era of impressive advances in dMRI acquisition and analysis. As a...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-08-01
|
| Series: | NeuroImage |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922002737 |
| _version_ | 1828323407134982144 |
|---|---|
| author | Anastasia Yendiki Manisha Aggarwal Markus Axer Amy F.D. Howard Anne-Marie van Cappellen van Walsum Suzanne N. Haber |
| author_facet | Anastasia Yendiki Manisha Aggarwal Markus Axer Amy F.D. Howard Anne-Marie van Cappellen van Walsum Suzanne N. Haber |
| author_sort | Anastasia Yendiki |
| collection | DOAJ |
| description | Diffusion MRI (dMRI) is a unique tool for the study of brain circuitry, as it allows us to image both the macroscopic trajectories and the microstructural properties of axon bundles in vivo. The Human Connectome Project ushered in an era of impressive advances in dMRI acquisition and analysis. As a result of these efforts, the quality of dMRI data that could be acquired in vivo improved substantially, and large collections of such data became widely available. Despite this progress, the main limitation of dMRI remains: it does not image axons directly, but only provides indirect measurements based on the diffusion of water molecules. Thus, it must be validated by methods that allow direct visualization of axons but that can only be performed in post mortem brain tissue. In this review, we discuss methods for validating the various features of connectional anatomy that are extracted from dMRI, both at the macro-scale (trajectories of axon bundles), and at micro-scale (axonal orientations and other microstructural properties). We present a range of validation tools, including anatomic tracer studies, Klingler's dissection, myelin stains, label-free optical imaging techniques, and others. We provide an overview of the basic principles of each technique, its limitations, and what it has taught us so far about the accuracy of different dMRI acquisition and analysis approaches. |
| first_indexed | 2024-04-13T18:52:08Z |
| format | Article |
| id | doaj.art-ce1a03da9a5b4e9fb8a4b4e7865702a2 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-13T18:52:08Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-ce1a03da9a5b4e9fb8a4b4e7865702a22022-12-22T02:34:23ZengElsevierNeuroImage1095-95722022-08-01256119146Post mortem mapping of connectional anatomy for the validation of diffusion MRIAnastasia Yendiki0Manisha Aggarwal1Markus Axer2Amy F.D. Howard3Anne-Marie van Cappellen van Walsum4Suzanne N. Haber5Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States; Corresponding authorDepartment of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesForschungszentrum Jülich, Institute of Neuroscience and Medicine, Jülich, Germany; Department of Physics, University of Wuppertal, GermanyWellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United KingdomDepartment of Medical Imaging, Anatomy, Radboud University Medical Center, Nijmegen, the Netherland; Cognition and Behaviour, Donders Institute for Brain, Nijmegen, the NetherlandDepartment of Pharmacology and Physiology, University of Rochester, Rochester, NY, United States; McLean Hospital, Belmont, MA, United StatesDiffusion MRI (dMRI) is a unique tool for the study of brain circuitry, as it allows us to image both the macroscopic trajectories and the microstructural properties of axon bundles in vivo. The Human Connectome Project ushered in an era of impressive advances in dMRI acquisition and analysis. As a result of these efforts, the quality of dMRI data that could be acquired in vivo improved substantially, and large collections of such data became widely available. Despite this progress, the main limitation of dMRI remains: it does not image axons directly, but only provides indirect measurements based on the diffusion of water molecules. Thus, it must be validated by methods that allow direct visualization of axons but that can only be performed in post mortem brain tissue. In this review, we discuss methods for validating the various features of connectional anatomy that are extracted from dMRI, both at the macro-scale (trajectories of axon bundles), and at micro-scale (axonal orientations and other microstructural properties). We present a range of validation tools, including anatomic tracer studies, Klingler's dissection, myelin stains, label-free optical imaging techniques, and others. We provide an overview of the basic principles of each technique, its limitations, and what it has taught us so far about the accuracy of different dMRI acquisition and analysis approaches.http://www.sciencedirect.com/science/article/pii/S1053811922002737 |
| spellingShingle | Anastasia Yendiki Manisha Aggarwal Markus Axer Amy F.D. Howard Anne-Marie van Cappellen van Walsum Suzanne N. Haber Post mortem mapping of connectional anatomy for the validation of diffusion MRI NeuroImage |
| title | Post mortem mapping of connectional anatomy for the validation of diffusion MRI |
| title_full | Post mortem mapping of connectional anatomy for the validation of diffusion MRI |
| title_fullStr | Post mortem mapping of connectional anatomy for the validation of diffusion MRI |
| title_full_unstemmed | Post mortem mapping of connectional anatomy for the validation of diffusion MRI |
| title_short | Post mortem mapping of connectional anatomy for the validation of diffusion MRI |
| title_sort | post mortem mapping of connectional anatomy for the validation of diffusion mri |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922002737 |
| work_keys_str_mv | AT anastasiayendiki postmortemmappingofconnectionalanatomyforthevalidationofdiffusionmri AT manishaaggarwal postmortemmappingofconnectionalanatomyforthevalidationofdiffusionmri AT markusaxer postmortemmappingofconnectionalanatomyforthevalidationofdiffusionmri AT amyfdhoward postmortemmappingofconnectionalanatomyforthevalidationofdiffusionmri AT annemarievancappellenvanwalsum postmortemmappingofconnectionalanatomyforthevalidationofdiffusionmri AT suzannenhaber postmortemmappingofconnectionalanatomyforthevalidationofdiffusionmri |