Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory
ObjectivesSeveral studies have examined the effects of repetitive transcranial magnetic stimulation (rTMS) on associative memory (AM) but findings were inconsistent. Here, we aimed to test whether twice-daily rTMS could significantly improve AM.MethodsIn this single-blind, sham-controlled experiment...
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Frontiers Media S.A.
2022-10-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.973298/full |
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| author | Qiang Hua Qiang Hua Qiang Hua Qiang Hua Yuanyuan Zhang Yuanyuan Zhang Yuanyuan Zhang Qianqian Li Qianqian Li Qianqian Li Xiaoran Gao Xiaoran Gao Xiaoran Gao Rongrong Du Rongrong Du Rongrong Du Yingru Wang Yingru Wang Yingru Wang Qian Zhou Qian Zhou Qian Zhou Ting Zhang Ting Zhang Ting Zhang Jinmei Sun Jinmei Sun Jinmei Sun Lei Zhang Lei Zhang Lei Zhang Lei Zhang Gong-jun Ji Gong-jun Ji Gong-jun Ji Gong-jun Ji Kai Wang Kai Wang Kai Wang Kai Wang Kai Wang Kai Wang |
| author_facet | Qiang Hua Qiang Hua Qiang Hua Qiang Hua Yuanyuan Zhang Yuanyuan Zhang Yuanyuan Zhang Qianqian Li Qianqian Li Qianqian Li Xiaoran Gao Xiaoran Gao Xiaoran Gao Rongrong Du Rongrong Du Rongrong Du Yingru Wang Yingru Wang Yingru Wang Qian Zhou Qian Zhou Qian Zhou Ting Zhang Ting Zhang Ting Zhang Jinmei Sun Jinmei Sun Jinmei Sun Lei Zhang Lei Zhang Lei Zhang Lei Zhang Gong-jun Ji Gong-jun Ji Gong-jun Ji Gong-jun Ji Kai Wang Kai Wang Kai Wang Kai Wang Kai Wang Kai Wang |
| author_sort | Qiang Hua |
| collection | DOAJ |
| description | ObjectivesSeveral studies have examined the effects of repetitive transcranial magnetic stimulation (rTMS) on associative memory (AM) but findings were inconsistent. Here, we aimed to test whether twice-daily rTMS could significantly improve AM.MethodsIn this single-blind, sham-controlled experiment, 40 participants were randomized to receive twice-daily sham or real rTMS sessions for five consecutive days (a total of 16,000 pulses). The stimulation target in left inferior parietal lobule (IPL) exhibiting peak functional connectivity to the left hippocampus was individually defined for each participant. Participants completed both a picture-cued word association task and Stroop test at baseline and 1 day after the final real or sham rTMS session. Effects of twice-daily rTMS on AM and Stroop test performance were compared using two-way repeated measures analysis of variance with main factors Group (real vs. sham) and Time (baseline vs. post-rTMS).ResultsThere was a significant Group × Time interaction effect. AM score was significantly enhanced in the twice-daily real group after rTMS, but this difference could not survive the post hoc analysis after multiple comparison correction. Further, AM improvement in the twice-daily real group was not superior to a previously reported once-daily rTMS group receiving 8,000 pulses. Then, we combined the twice- and once-daily real groups, and found a significant Group × Time interaction effect. Post hoc analysis indicated that the AM score was significantly enhanced in the real group after multiple comparisons correction.ConclusionOur prospective experiment did not show significant rTMS effect on AM, but this effect may become significant if more participants could be recruited as revealed by our retrospective analysis. |
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| spelling | doaj.art-ce1ab39df76f46aba424292c8c9730a12022-12-22T02:23:29ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-10-011610.3389/fnhum.2022.973298973298Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memoryQiang Hua0Qiang Hua1Qiang Hua2Qiang Hua3Yuanyuan Zhang4Yuanyuan Zhang5Yuanyuan Zhang6Qianqian Li7Qianqian Li8Qianqian Li9Xiaoran Gao10Xiaoran Gao11Xiaoran Gao12Rongrong Du13Rongrong Du14Rongrong Du15Yingru Wang16Yingru Wang17Yingru Wang18Qian Zhou19Qian Zhou20Qian Zhou21Ting Zhang22Ting Zhang23Ting Zhang24Jinmei Sun25Jinmei Sun26Jinmei Sun27Lei Zhang28Lei Zhang29Lei Zhang30Lei Zhang31Gong-jun Ji32Gong-jun Ji33Gong-jun Ji34Gong-jun Ji35Kai Wang36Kai Wang37Kai Wang38Kai Wang39Kai Wang40Kai Wang41Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaHefei Comprehensive National Science Center, Institute of Artificial Intelligence, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, ChinaSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, ChinaCollaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, ChinaHefei Comprehensive National Science Center, Institute of Artificial Intelligence, Hefei, ChinaAnhui Institute of Translational Medicine, Hefei, ChinaObjectivesSeveral studies have examined the effects of repetitive transcranial magnetic stimulation (rTMS) on associative memory (AM) but findings were inconsistent. Here, we aimed to test whether twice-daily rTMS could significantly improve AM.MethodsIn this single-blind, sham-controlled experiment, 40 participants were randomized to receive twice-daily sham or real rTMS sessions for five consecutive days (a total of 16,000 pulses). The stimulation target in left inferior parietal lobule (IPL) exhibiting peak functional connectivity to the left hippocampus was individually defined for each participant. Participants completed both a picture-cued word association task and Stroop test at baseline and 1 day after the final real or sham rTMS session. Effects of twice-daily rTMS on AM and Stroop test performance were compared using two-way repeated measures analysis of variance with main factors Group (real vs. sham) and Time (baseline vs. post-rTMS).ResultsThere was a significant Group × Time interaction effect. AM score was significantly enhanced in the twice-daily real group after rTMS, but this difference could not survive the post hoc analysis after multiple comparison correction. Further, AM improvement in the twice-daily real group was not superior to a previously reported once-daily rTMS group receiving 8,000 pulses. Then, we combined the twice- and once-daily real groups, and found a significant Group × Time interaction effect. Post hoc analysis indicated that the AM score was significantly enhanced in the real group after multiple comparisons correction.ConclusionOur prospective experiment did not show significant rTMS effect on AM, but this effect may become significant if more participants could be recruited as revealed by our retrospective analysis.https://www.frontiersin.org/articles/10.3389/fnhum.2022.973298/fullassociative memoryhippocampal-cortical networkinferior parietal lobulestimulation dosetranscranial magnetic stimulation |
| spellingShingle | Qiang Hua Qiang Hua Qiang Hua Qiang Hua Yuanyuan Zhang Yuanyuan Zhang Yuanyuan Zhang Qianqian Li Qianqian Li Qianqian Li Xiaoran Gao Xiaoran Gao Xiaoran Gao Rongrong Du Rongrong Du Rongrong Du Yingru Wang Yingru Wang Yingru Wang Qian Zhou Qian Zhou Qian Zhou Ting Zhang Ting Zhang Ting Zhang Jinmei Sun Jinmei Sun Jinmei Sun Lei Zhang Lei Zhang Lei Zhang Lei Zhang Gong-jun Ji Gong-jun Ji Gong-jun Ji Gong-jun Ji Kai Wang Kai Wang Kai Wang Kai Wang Kai Wang Kai Wang Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory Frontiers in Human Neuroscience associative memory hippocampal-cortical network inferior parietal lobule stimulation dose transcranial magnetic stimulation |
| title | Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory |
| title_full | Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory |
| title_fullStr | Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory |
| title_full_unstemmed | Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory |
| title_short | Efficacy of twice-daily high-frequency repetitive transcranial magnetic stimulation on associative memory |
| title_sort | efficacy of twice daily high frequency repetitive transcranial magnetic stimulation on associative memory |
| topic | associative memory hippocampal-cortical network inferior parietal lobule stimulation dose transcranial magnetic stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.973298/full |
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