Research progress on antimicrobial peptides in terms of the prevention and treatment of dental caries
Antimicrobial peptides have antibacterial effects on various pathogenic microorganisms, including natural antimicrobial peptides and synthetic antimicrobial peptides. According to the structure of natural antimicrobial peptides, synthetic antimicrobial peptides can be obtained by recombining differe...
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| Aineistotyyppi: | Artikkeli |
| Kieli: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2023-06-01
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| Sarja: | 口腔疾病防治 |
| Aiheet: | |
| Linkit: | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.06.008 |
| _version_ | 1828001653358329856 |
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| author | ZHU He CHENG Xingqun WU Hongkun |
| author_facet | ZHU He CHENG Xingqun WU Hongkun |
| author_sort | ZHU He |
| collection | DOAJ |
| description | Antimicrobial peptides have antibacterial effects on various pathogenic microorganisms, including natural antimicrobial peptides and synthetic antimicrobial peptides. According to the structure of natural antimicrobial peptides, synthetic antimicrobial peptides can be obtained by recombining different functional domains, adjusting the original amino acid sequence, or completely redesigning the peptides from scratch. Antimicrobial peptides can inhibit the growth of various cariogenic microorganisms and the formation of microbial biofilms. They also reduce acid production and acid resistance of microorganisms. Natural antimicrobial peptide genes can be used as genetic susceptibility markers for predicting the development of caries, thus, showing potential applications in the prevention and treatment of dental caries. The instability of natural antimicrobial peptides and the inability to achieve targeted sustained release limit their application in the prevention and treatment of oral caries. Synthetic antimicrobial peptides can enhance their stability and the antibacterial effect. Synthetic antimicrobial peptides can also be polymerized with common oral adhesives to reduce the incidence of microleakage after filling treatment for caries and to prevent the occurrence of secondary caries. The pH-sensitive antimicrobial peptides are slowly released to promote remineralization in the process of caries. However, the safety and biocompatibility of synthetic antimicrobial peptides are worse than those of natural antimicrobial peptides. Moreover, the combined effect of antibacterial peptides and anticaries drugs, such as fluoride, is still uncertain. Therefore, in this paper, we will review the design methods, application and underlying mechanisms of antimicrobial peptides to introduce novel methods and ideas for the prevention and treatment of dental caries. |
| first_indexed | 2024-04-10T06:32:17Z |
| format | Article |
| id | doaj.art-ce1ba6d0e7b14df1abcf8c5b7e7dbf39 |
| institution | Directory Open Access Journal |
| issn | 2096-1456 |
| language | zho |
| last_indexed | 2024-04-10T06:32:17Z |
| publishDate | 2023-06-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-ce1ba6d0e7b14df1abcf8c5b7e7dbf392023-03-01T07:09:29ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562023-06-0131643443910.12016/j.issn.2096⁃1456.2023.06.008Research progress on antimicrobial peptides in terms of the prevention and treatment of dental cariesZHU He 0 CHENG Xingqun1 WU Hongkun 2State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Geriatric Dentistry, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Geriatric Dentistry, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Geriatric Dentistry, West China Hospital of Stomatology, Sichuan UniversityAntimicrobial peptides have antibacterial effects on various pathogenic microorganisms, including natural antimicrobial peptides and synthetic antimicrobial peptides. According to the structure of natural antimicrobial peptides, synthetic antimicrobial peptides can be obtained by recombining different functional domains, adjusting the original amino acid sequence, or completely redesigning the peptides from scratch. Antimicrobial peptides can inhibit the growth of various cariogenic microorganisms and the formation of microbial biofilms. They also reduce acid production and acid resistance of microorganisms. Natural antimicrobial peptide genes can be used as genetic susceptibility markers for predicting the development of caries, thus, showing potential applications in the prevention and treatment of dental caries. The instability of natural antimicrobial peptides and the inability to achieve targeted sustained release limit their application in the prevention and treatment of oral caries. Synthetic antimicrobial peptides can enhance their stability and the antibacterial effect. Synthetic antimicrobial peptides can also be polymerized with common oral adhesives to reduce the incidence of microleakage after filling treatment for caries and to prevent the occurrence of secondary caries. The pH-sensitive antimicrobial peptides are slowly released to promote remineralization in the process of caries. However, the safety and biocompatibility of synthetic antimicrobial peptides are worse than those of natural antimicrobial peptides. Moreover, the combined effect of antibacterial peptides and anticaries drugs, such as fluoride, is still uncertain. Therefore, in this paper, we will review the design methods, application and underlying mechanisms of antimicrobial peptides to introduce novel methods and ideas for the prevention and treatment of dental caries.http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.06.008dental caries ，cariogenic bacteria ，biofilm ，oral microecology ，remineralization ，secondary caries，antimicrobial peptide ，targeted sustained release ，antibacterial effect， |
| spellingShingle | ZHU He CHENG Xingqun WU Hongkun Research progress on antimicrobial peptides in terms of the prevention and treatment of dental caries 口腔疾病防治 dental caries ， cariogenic bacteria ， biofilm ， oral microecology ， remineralization ， secondary caries， antimicrobial peptide ， targeted sustained release ， antibacterial effect， |
| title | Research progress on antimicrobial peptides in terms of the prevention and treatment of dental caries |
| title_full | Research progress on antimicrobial peptides in terms of the prevention and treatment of dental caries |
| title_fullStr | Research progress on antimicrobial peptides in terms of the prevention and treatment of dental caries |
| title_full_unstemmed | Research progress on antimicrobial peptides in terms of the prevention and treatment of dental caries |
| title_short | Research progress on antimicrobial peptides in terms of the prevention and treatment of dental caries |
| title_sort | research progress on antimicrobial peptides in terms of the prevention and treatment of dental caries |
| topic | dental caries ， cariogenic bacteria ， biofilm ， oral microecology ， remineralization ， secondary caries， antimicrobial peptide ， targeted sustained release ， antibacterial effect， |
| url | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.06.008 |
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