The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline Phosphatase
Objectives Nowadays most infants on exclusively breast feeding have vitamin D deficiency due to the increase of breast feeding. However, domestic research lacks appropriate materials. Therefore, we researched practical clinical aspects of vitamin D deficiency related to breast milk feeding for infan...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2012-06-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc027-1-03.pdf |
| _version_ | 1797989195674812416 |
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| author | Ji Sung Kim Jae Yong Choi Kyun Woo Lee Ick Jin Song Cheol Am Kim Byeong Hee Son Jung Hyun Lee |
| author_facet | Ji Sung Kim Jae Yong Choi Kyun Woo Lee Ick Jin Song Cheol Am Kim Byeong Hee Son Jung Hyun Lee |
| author_sort | Ji Sung Kim |
| collection | DOAJ |
| description | Objectives Nowadays most infants on exclusively breast feeding have vitamin D deficiency due to the increase of breast feeding. However, domestic research lacks appropriate materials. Therefore, we researched practical clinical aspects of vitamin D deficiency related to breast milk feeding for infants who have a high amount of alkaline phosphatase (> 500 IU/L). Methods The subjects of the study were 31 infants with high alkaline phosphatase level. We tested with 25-hydroxycholecalciferol (25-OHD3), parathyroid hormone, calcium, ionized calcium, phosphorus in their blood and with a wrist x-ray. Then, we divided them into two groups of breast feeding and formula feeding and compared the results. Results Eighteen infants (58%) out of 31 infants that have high alkaline phosphatase were vitamin D insufficiency or deficiency, and 16 (100%) breast feeding infants of them showed vitamin D deficiency or insufficiency. However, only 2 (13%) of 15 formula feeding infants were at insufficiency. There was a correlation between alkaline phosphatase and 25-OHD3 concentration in multiple regression analysis, but no correlation in other variables was found in group of breast milk feeding infants. There was neither correlation between vitamin D concentration and alkaline phosphatase nor other correlated variables in the group of formula milk feeding infants. Conclusions In this study, there was a high probability of vitamin D deficiency in the breast feeding infants with a high alkaline phosphatase level. Therefore, it is considered to be worth utilizing alkaline phosphatase as a screening test for vitamin D deficiency or rickets for breast feeding infants. |
| first_indexed | 2024-04-11T08:16:21Z |
| format | Article |
| id | doaj.art-ce1e6907c7dd4e8cbb388105e5976a7c |
| institution | Directory Open Access Journal |
| issn | 2005-9531 |
| language | English |
| last_indexed | 2024-04-11T08:16:21Z |
| publishDate | 2012-06-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-ce1e6907c7dd4e8cbb388105e5976a7c2022-12-22T04:35:10ZengKosin University College of MedicineKosin Medical Journal2005-95312012-06-01271172410.7180/kmj.2012.27.1.1712The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline PhosphataseJi Sung Kim0Jae Yong Choi1Kyun Woo Lee2Ick Jin Song3Cheol Am Kim4Byeong Hee Son5Jung Hyun Lee6Department of Pediatrics, Dae-Dong Hospital, Busan, Korea.Department of Pediatrics, Dae-Dong Hospital, Busan, Korea.Department of Pediatrics, Dae-Dong Hospital, Busan, Korea.Department of Pediatrics, Dae-Dong Hospital, Busan, Korea.Department of Pediatrics, Dae-Dong Hospital, Busan, Korea.Department of Pediatrics, Dae-Dong Hospital, Busan, Korea.Department of Pediatrics, College of Medicine, Kosin University, Busan, Korea.Objectives Nowadays most infants on exclusively breast feeding have vitamin D deficiency due to the increase of breast feeding. However, domestic research lacks appropriate materials. Therefore, we researched practical clinical aspects of vitamin D deficiency related to breast milk feeding for infants who have a high amount of alkaline phosphatase (> 500 IU/L). Methods The subjects of the study were 31 infants with high alkaline phosphatase level. We tested with 25-hydroxycholecalciferol (25-OHD3), parathyroid hormone, calcium, ionized calcium, phosphorus in their blood and with a wrist x-ray. Then, we divided them into two groups of breast feeding and formula feeding and compared the results. Results Eighteen infants (58%) out of 31 infants that have high alkaline phosphatase were vitamin D insufficiency or deficiency, and 16 (100%) breast feeding infants of them showed vitamin D deficiency or insufficiency. However, only 2 (13%) of 15 formula feeding infants were at insufficiency. There was a correlation between alkaline phosphatase and 25-OHD3 concentration in multiple regression analysis, but no correlation in other variables was found in group of breast milk feeding infants. There was neither correlation between vitamin D concentration and alkaline phosphatase nor other correlated variables in the group of formula milk feeding infants. Conclusions In this study, there was a high probability of vitamin D deficiency in the breast feeding infants with a high alkaline phosphatase level. Therefore, it is considered to be worth utilizing alkaline phosphatase as a screening test for vitamin D deficiency or rickets for breast feeding infants.http://www.kosinmedj.org/upload/pdf/ksmc027-1-03.pdfalkaline phosphatasevitamin d deficiencybreast feeding |
| spellingShingle | Ji Sung Kim Jae Yong Choi Kyun Woo Lee Ick Jin Song Cheol Am Kim Byeong Hee Son Jung Hyun Lee The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline Phosphatase Kosin Medical Journal alkaline phosphatase vitamin d deficiency breast feeding |
| title | The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline Phosphatase |
| title_full | The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline Phosphatase |
| title_fullStr | The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline Phosphatase |
| title_full_unstemmed | The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline Phosphatase |
| title_short | The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline Phosphatase |
| title_sort | study in vitamin d concentration in the blood for infants with high level of alkaline phosphatase |
| topic | alkaline phosphatase vitamin d deficiency breast feeding |
| url | http://www.kosinmedj.org/upload/pdf/ksmc027-1-03.pdf |
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