Evaluation of a Clinically Relevant Drug–Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity

Evaluation of a Clinically Relevant Drug–Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity

Purpose: The combination therapy of rosuvastatin (RSV) and the platelet inhibitor clopidogrel (CP) is widely accepted in the management of cardiovascular diseases. The objective of the present study was to identify the mechanism of RSV–CP DDI and evaluate the risk of hepatotoxicity associated with t...

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Bibliographic Details
Main Authors: Chen Ning, Shengdi Su, Jiaming Li, Dexuan Kong, Hui Cai, Zhiying Qin, Han Xing, Xijing Chen, Jiake He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
rosuvastatin
clopidogrel
drug–drug interaction
transport
hepatotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.715577/full

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