Cascade synthesis of uridine-5′-diphosphate glucuronic acid by coupling multiple whole cells expressing hyperthermophilic enzymes

Cascade synthesis of uridine-5′-diphosphate glucuronic acid by coupling multiple whole cells expressing hyperthermophilic enzymes

Abstract Background Enzymatic glycan synthesis has leapt forward in recent years and a number of glucuronosyltransferase (EC 2.4.1.17) have been identified and prepared, which provides a guide to an efficient approach to prepare glycans containing glucuronic acid (GlcA) residues. The uridine 5′-diph...

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Bibliographic Details
Main Authors: Dan-Hua Meng, Ran-Ran Du, Lu-Zhou Chen, Meng-Ting Li, Fei Liu, Jin Hou, Yi-Kang Shi, Feng-Shan Wang, Ju-Zheng Sheng
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Microbial Cell Factories
Subjects:
Biocatalysis
Whole cell synthesis
Nucleotide sugar
UDP-GlcA
Hyperthermophilic enzyme
NAD+ regeneration
Online Access:http://link.springer.com/article/10.1186/s12934-019-1168-z

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