Gamma-Chain Receptor Cytokines & PD-1 Manipulation to Restore HCV-Specific CD8<sup>+</sup> T Cell Response during Chronic Hepatitis C

Gamma-Chain Receptor Cytokines & PD-1 Manipulation to Restore HCV-Specific CD8<sup>+</sup> T Cell Response during Chronic Hepatitis C

Hepatitis C virus (HCV)-specific CD8<sup>+</sup> T cell response is essential in natural HCV infection control, but it becomes exhausted during persistent infection. Nowadays, chronic HCV infection can be resolved by direct acting anti-viral treatment, but there are still some non-respon...

Full description

Bibliographic Details
Main Authors:	Julia Peña-Asensio, Henar Calvo, Miguel Torralba, Joaquín Miquel, Eduardo Sanz-de-Villalobos, Juan-Ramón Larrubia
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Cells
Subjects:	Hepatitis C virus CD8<sup>+</sup> T cell response exhaustion immune checkpoints γ-chain cytokines PD-1
Online Access:	https://www.mdpi.com/2073-4409/10/3/538

Similar Items

CD8<sup>+</sup> T Cell Responses during HCV Infection and HCC
by: Maike Hofmann, et al.
Published: (2021-03-01)

PD-1<sup>+</sup>CD8<sup>+</sup> T Cells Proximal to PD-L1<sup>+</sup>CD68<sup>+</sup> Macrophages Are Associated with Poor Prognosis in Pancreatic Ductal Adenocarcinoma Patients
by: Xiaobao Yang, et al.
Published: (2023-02-01)

Glutamate-Evoked Ca<sup>2+</sup> Responses in the Rat Suprachiasmatic Nucleus: Involvement of Na<sup>+</sup>/K<sup>+</sup>-ATPase and Na<sup>+</sup>/Ca<sup>2+</sup>-Exchanger
by: Pi-Cheng Cheng, et al.
Published: (2023-03-01)

Heterotridentate Organomonophosphines in Pt(κ<sup>3</sup>–X<sup>1</sup>P<sup>1</sup>X<sup>2</sup>)(Y) (X<sup>1,2</sup> = N<sup>1,2</sup> or S<sup>1,2</sup>), Pt(κ<sup>3</sup>–P<sup>1</sup>N<sup>1</sup>X<sup>1</sup>)(Y) (X<sup>1</sup> = O, C, S or Se) Pt(κ<sup>3</sup>–P<sup>1</sup>S<sup>1</sup>Cl<sup>1</sup>)(Cl) and Pt(κ<sup>3</sup>–P<sup>1</sup>Si<sup>1</sup>N<sup>1</sup>)(OL)—Structural Aspects
by: Milan Melník, et al.
Published: (2022-12-01)

Na<sup>+</sup>,K<sup>+</sup>-ATPase with Disrupted Na<sup>+</sup> Binding Sites I and III Binds Na<sup>+</sup> with Increased Affinity at Site II and Undergoes Na<sup>+</sup>-Activated Phosphorylation with ATP
by: Hang N. Nielsen, et al.
Published: (2024-01-01)

Study on the Effect of Gamma-Ray Irradiation on the Adsorption of <sup>99</sup>Tc and Re by a Silica-Based Pyridine Resin
by: Hongji Sang, et al.
Published: (2022-10-01)

ES-SCLC Patients with PD-L1<sup>+</sup> CTCs and High Percentages of CD8<sup>+</sup>PD-1<sup>+</sup>T Cells in Circulation Benefit from Front-Line Immunotherapy Treatment
by: Anastasia Xagara, et al.
Published: (2024-01-01)

In-vitro inhibition of IFNγ<sup>+</sup> iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function
by: Daniel Volker, et al.
Published: (2012-08-01)

Lanthanide (Eu<sup>3+</sup>/Tb<sup>3+</sup>)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan
by: Yaowei Guo, et al.
Published: (2022-06-01)

Organomonophosphines in Pt(η<sup>3</sup>-X<sup>1</sup>X<sup>2</sup>X<sup>3</sup>)(PR<sub>3</sub>), (X = N<sup>1</sup>, N<sup>2</sup>, N<sup>3</sup>; S<sup>1</sup>, S<sup>2</sup>, S<sup>3</sup>; or Te<sup>1</sup>, Te<sup>2</sup>, Te<sup>3</sup>) Derivatives: Structural Aspects
by: Milan Melník, et al.
Published: (2023-06-01)

The Pseudo-Protic Ionic Liquids TOAH<sup>+</sup>Cl<sup>−</sup> and TODAH<sup>+</sup>Cl<sup>−</sup> as Carriers for Facilitated Transport of In(III) from HCl Solutions
by: Francisco José Alguacil, et al.
Published: (2022-12-01)

Regulatory Mechanisms and Reversal of CD8<sup>+</sup>T Cell Exhaustion: A Literature Review
by: Wanwan Zhu, et al.
Published: (2023-04-01)

Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose<sup>®</sup> 80, CombiLac<sup>®</sup>, MicroceLac<sup>®</sup> 100, and StarLac<sup>®</sup>
by: Martin Dominik, et al.
Published: (2021-09-01)

Opposing Roles of DCs and iNKT Cells in the Induction of Foxp3 Expression by MLN CD25<sup>+</sup>CD4<sup>+</sup> T Cells during IFNγ-Driven Colitis
by: Sung Won Lee, et al.
Published: (2022-12-01)

K<sup>+</sup> and Ca<sup>2+</sup> Channels Regulate Ca<sup>2+</sup> Signaling in Chondrocytes: An Illustrated Review
by: Yoshiaki Suzuki, et al.
Published: (2020-06-01)

Double Positive CD4<sup>+</sup>CD8<sup>+</sup> (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C
by: Anna Maria Kochanowicz, et al.
Published: (2023-05-01)

Safranal Induces Vasorelaxation by Inhibiting Ca<sup>2+</sup> Influx and Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Isolated Rat Aortic Rings
by: Noor Nadhim Al-Saigh, et al.
Published: (2022-06-01)

Rare Earth Elements Geochemistry and <sup>234</sup>U/<sup>238</sup>U, <sup>235</sup>U/<sup>238</sup>U Isotope Ratios of the Kanyakumari Beach Placer Deposits: Occurrence and Provenance
by: Thennaarassan Natarajan, et al.
Published: (2023-06-01)

Mitochondrial DNA tRNA<sup>Leu</sup> and tRNA<sup>Ser</sup> polymorphism in different pig breeds
by: M. A. Kolosova, et al.
Published: (2018-10-01)

Luminescence and Gamma Spectroscopy of Phosphate Glass Doped with Nd<sup>3+</sup>/Yb<sup>3+</sup> and Their Multifunctional Applications
by: Bilel Charfi, et al.
Published: (2022-06-01)

Chemical Separation of Uranium and Precise Measurement of <sup>234</sup>U/<sup>238</sup>U and <sup>235</sup>U/<sup>238</sup>U Ratios in Soil Samples Using Multi Collector Inductively Coupled Plasma Mass Spectrometry
by: Nimelan Veerasamy, et al.
Published: (2020-05-01)

Meteoric <sup>10</sup>Be, <sup>137</sup>Cs and <sup>239+240</sup>Pu as Tracers of Long- and Medium-Term Soil Erosion—A Review
by: Aleksandra Loba, et al.
Published: (2022-03-01)

Modulation of CD8<sup>+</sup> T Cell Responses by Radiotherapy—Current Evidence and Rationale for Combination with Immune Checkpoint Inhibitors
by: Seung Hyuck Jeon, et al.
Published: (2023-11-01)

Wound Repair and Ca<sup>2+</sup> Signalling Interplay: The Role of Ca<sup>2+</sup> Channels in Skin
by: Gregorio Bonsignore, et al.
Published: (2024-03-01)

Piezoelectric A<sup>15</sup>B<sup>16</sup>C<sup>17</sup> Compounds and Their Nanocomposites for Energy Harvesting and Sensors: A Review
by: Piotr Szperlich
Published: (2021-11-01)

Inhibition of Voltage-Gated Na<sup>+</sup> Currents Exerted by KB-R7943 (2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea), an Inhibitor of Na<sup>+</sup>-Ca<sup>2+</sup> Exchanging Process
by: Sheng-Nan Wu, et al.
Published: (2023-01-01)

Spinach Plants Favor the Absorption of K<sup>+</sup> over Na<sup>+</sup> Regardless of Salinity, and May Benefit from Na<sup>+</sup> When K<sup>+</sup> is Deficient in the Soil
by: Jorge F. S. Ferreira, et al.
Published: (2020-04-01)

Heat-Affected-Zone Liquation Cracking in Welded Cast Haynes<sup>®</sup> 282<sup>®</sup>
by: Sukhdeep Singh, et al.
Published: (2019-12-01)

Preparation and Preliminary Evaluation of Neurotensin Radiolabelled with <sup>68</sup>Ga and <sup>177</sup>Lu as Potential Theranostic Agent for Colon Cancer
by: Radu Anton Leonte, et al.
Published: (2021-04-01)

<sup>7</sup>Be, <sup>210</sup>Pb<sub>atm</sub> and <sup>137</sup>Cs in Snow Deposits in the Arctic Part of Western Siberia (Yamal-Nenets Autonomous District)
by: Kseniya Mezina, et al.
Published: (2020-08-01)

The Reliability of ClinCheck<sup>®</sup> Accuracy before and after Invisalign<sup>®</sup> Treatment—A Multicenter Retrospective Study
by: Wafa Alswajy, et al.
Published: (2023-04-01)

CD3<sup>+</sup>, CD8<sup>+</sup>, CD4<sup>+</sup> and FOXP3<sup>+</sup> T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors
by: Niko Hiltunen, et al.
Published: (2021-06-01)

Determination of <sup>238</sup>U and <sup>40</sup>K Radionuclide Concentrations in Some Granite Rocks by Gamma Spectroscopy and Energy Dispersive X-ray Analysis
by: Hanan Al-Ghamdi, et al.
Published: (2022-07-01)

CD4<sup>+</sup> T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease
by: Yi-Hsing Chen, et al.
Published: (2021-09-01)

Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine
by: Yiting Chen, et al.
Published: (2020-08-01)

Physiological and Pathophysiological Roles of Mitochondrial Na<sup>+</sup>-Ca<sup>2+</sup> Exchanger, NCLX, in Hearts
by: Ayako Takeuchi, et al.
Published: (2021-12-01)

Effects of Oregano Essential Oil on IgA<sup>+</sup>, IgG<sup>+</sup>, and IgM<sup>+</sup> Cells in the Jejunum of Castrated Holstein Bulls
by: Qiyan Liu, et al.
Published: (2023-12-01)

A Multifunctional Fluorescent Probe Based on 1,8-Naphthalimide for the Detection of Co<sup>2+</sup>, F<sup>−</sup>, and CN<sup>−</sup>
by: Ping Li, et al.
Published: (2023-06-01)

Adsorption of Hydrated Pr<sup>3+</sup> and NH<sub>4</sub><sup>+</sup>/Mg<sup>2+</sup> Ions onto the (001) Surface of Montmorillonite: A DFT Analysis with Experimental Verification
by: Zhiqiang Zou, et al.
Published: (2022-11-01)

Anti-PD-1/PD-L1 Based Combination Immunotherapy to Boost Antigen-Specific CD8<sup>+</sup> T Cell Response in Hepatocellular Carcinoma
by: Julia Peña-Asensio, et al.
Published: (2021-04-01)