Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota
The aim of this study was to analyze the link between periodontal microbiota and obesity in humans. We conducted a cohort study including 45 subjects with periodontitis divided into two groups: normo-weighted subjects with a body mass index (BMI) between 20 and 25 kg/m<sup>2</sup> (<i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/20/15123 |
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| author | Sylvie Lê Sara Laurencin-Dalicieux Matthieu Minty Justine Assoulant-Anduze Alexia Vinel Noor Yanat Pascale Loubieres Vincent Azalbert Swann Diemer Remy Burcelin Thibault Canceill Charlotte Thomas Vincent Blasco-Baque |
| author_facet | Sylvie Lê Sara Laurencin-Dalicieux Matthieu Minty Justine Assoulant-Anduze Alexia Vinel Noor Yanat Pascale Loubieres Vincent Azalbert Swann Diemer Remy Burcelin Thibault Canceill Charlotte Thomas Vincent Blasco-Baque |
| author_sort | Sylvie Lê |
| collection | DOAJ |
| description | The aim of this study was to analyze the link between periodontal microbiota and obesity in humans. We conducted a cohort study including 45 subjects with periodontitis divided into two groups: normo-weighted subjects with a body mass index (BMI) between 20 and 25 kg/m<sup>2</sup> (<i>n</i> = 34) and obese subjects with a BMI > 30 kg/m<sup>2</sup> (<i>n</i> = 11). Our results showed that obesity was associated with significantly more severe gingival inflammation according to Periodontal Inflamed Surface Area (PISA index). Periodontal microbiota taxonomic analysis showed that the obese (OB) subjects with periodontitis were characterized by a specific signature of subgingival microbiota with an increase in Gram-positive bacteria in periodontal pockets, associated with a decrease in microbiota diversity compared to that of normo-weighted subjects with periodontitis. Finally, periodontal treatment response was less effective in OB subjects with persisting periodontal inflammation, reflecting a still unstable periodontal condition and a risk of recurrence. To our knowledge, this study is the first exploring both salivary and subgingival microbiota of OB subjects. Considering that OB subjects are at higher periodontal risk, this could lead to more personalized preventive or therapeutic strategies for obese patients regarding periodontitis through the specific management of oral microbiota of obese patients. |
| first_indexed | 2024-03-10T21:13:08Z |
| format | Article |
| id | doaj.art-ce2371265eac43b7ab4d7b19636e06e2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:13:08Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ce2371265eac43b7ab4d7b19636e06e22023-11-19T16:41:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124201512310.3390/ijms242015123Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival MicrobiotaSylvie Lê0Sara Laurencin-Dalicieux1Matthieu Minty2Justine Assoulant-Anduze3Alexia Vinel4Noor Yanat5Pascale Loubieres6Vincent Azalbert7Swann Diemer8Remy Burcelin9Thibault Canceill10Charlotte Thomas11Vincent Blasco-Baque12Département d’Odontologie, Faculté de Santé, Université Paul Sabatier Toulouse III, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, FranceDépartement d’Odontologie, Faculté de Santé, Université Paul Sabatier Toulouse III, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, FranceDépartement d’Odontologie, Faculté de Santé, Université Paul Sabatier Toulouse III, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, FranceUMR1297 Inserm, Team InCOMM/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Paul Sabatier, 1 Avenue Jean Poulhes, 31432 Toulouse, FranceDépartement d’Odontologie, Faculté de Santé, Université Paul Sabatier Toulouse III, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, FranceDépartement d’Odontologie, Faculté de Santé, Université Paul Sabatier Toulouse III, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, FranceDépartement d’Odontologie, Faculté de Santé, Université Paul Sabatier Toulouse III, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, FranceUMR1297 Inserm, Team InCOMM/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Paul Sabatier, 1 Avenue Jean Poulhes, 31432 Toulouse, FranceUMR1297 Inserm, Team InCOMM/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Paul Sabatier, 1 Avenue Jean Poulhes, 31432 Toulouse, FranceUMR1297 Inserm, Team InCOMM/Intestine ClinicOmics Metabolism & Microbiota, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Paul Sabatier, 1 Avenue Jean Poulhes, 31432 Toulouse, FranceDépartement d’Odontologie, Faculté de Santé, Université Paul Sabatier Toulouse III, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, FranceDépartement d’Odontologie, Faculté de Santé, Université Paul Sabatier Toulouse III, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, FranceDépartement d’Odontologie, Faculté de Santé, Université Paul Sabatier Toulouse III, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, FranceThe aim of this study was to analyze the link between periodontal microbiota and obesity in humans. We conducted a cohort study including 45 subjects with periodontitis divided into two groups: normo-weighted subjects with a body mass index (BMI) between 20 and 25 kg/m<sup>2</sup> (<i>n</i> = 34) and obese subjects with a BMI > 30 kg/m<sup>2</sup> (<i>n</i> = 11). Our results showed that obesity was associated with significantly more severe gingival inflammation according to Periodontal Inflamed Surface Area (PISA index). Periodontal microbiota taxonomic analysis showed that the obese (OB) subjects with periodontitis were characterized by a specific signature of subgingival microbiota with an increase in Gram-positive bacteria in periodontal pockets, associated with a decrease in microbiota diversity compared to that of normo-weighted subjects with periodontitis. Finally, periodontal treatment response was less effective in OB subjects with persisting periodontal inflammation, reflecting a still unstable periodontal condition and a risk of recurrence. To our knowledge, this study is the first exploring both salivary and subgingival microbiota of OB subjects. Considering that OB subjects are at higher periodontal risk, this could lead to more personalized preventive or therapeutic strategies for obese patients regarding periodontitis through the specific management of oral microbiota of obese patients.https://www.mdpi.com/1422-0067/24/20/15123oral microbiotasubgingival microbiotaperiodontitisobesityperiodontal inflammationPISA |
| spellingShingle | Sylvie Lê Sara Laurencin-Dalicieux Matthieu Minty Justine Assoulant-Anduze Alexia Vinel Noor Yanat Pascale Loubieres Vincent Azalbert Swann Diemer Remy Burcelin Thibault Canceill Charlotte Thomas Vincent Blasco-Baque Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota International Journal of Molecular Sciences oral microbiota subgingival microbiota periodontitis obesity periodontal inflammation PISA |
| title | Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota |
| title_full | Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota |
| title_fullStr | Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota |
| title_full_unstemmed | Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota |
| title_short | Obesity Is Associated with the Severity of Periodontal Inflammation Due to a Specific Signature of Subgingival Microbiota |
| title_sort | obesity is associated with the severity of periodontal inflammation due to a specific signature of subgingival microbiota |
| topic | oral microbiota subgingival microbiota periodontitis obesity periodontal inflammation PISA |
| url | https://www.mdpi.com/1422-0067/24/20/15123 |
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