Inducible clindamycin resistance in Staphylococci: Should clinicians and microbiologists be concerned?
The increasing incidence of a variety of infections due to Staphylococcus aureus and the expanding role of community-associated methicillin-resistant S. aureus has led to an emphasis on the need for safe and effective agents to treat both systemic and localized Staphylococcal infections. Several new...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2012-01-01
|
| Series: | Journal of the Scientific Society |
| Subjects: | |
| Online Access: | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2012;volume=39;issue=1;spage=7;epage=9;aulast=Kamat |
| _version_ | 1811288146710626304 |
|---|---|
| author | Madhumati Kamat M A Vagarali S G Karadesai |
| author_facet | Madhumati Kamat M A Vagarali S G Karadesai |
| author_sort | Madhumati Kamat |
| collection | DOAJ |
| description | The increasing incidence of a variety of infections due to Staphylococcus aureus and the expanding role of community-associated methicillin-resistant S. aureus has led to an emphasis on the need for safe and effective agents to treat both systemic and localized Staphylococcal infections. Several newer antimicrobial agents are available for treatment of systemic Staphylococcal infections, but their use may be limited by the relatively high cost of these agents or the need forparenteral administration. Clindamycin has been used successfully to treat soft-tissue and musculoskeletal infections due to MRSA, in adults and children. However, concern over the possibility of the emergence of clindamycin resistance during therapy has discouraged some clinicians from prescribing that agent. Simple laboratory testing (e.g., the erythromycin-clindamycin ′D-zone′ test) can separate strains that have the genetic potential (i.e., the presence of erm genes) to become resistant during therapy, from strains that are fully susceptible to clindamycin. |
| first_indexed | 2024-04-13T03:31:00Z |
| format | Article |
| id | doaj.art-ce246f18a6d6466b95ddecaa8cc61e25 |
| institution | Directory Open Access Journal |
| issn | 0974-5009 |
| language | English |
| last_indexed | 2024-04-13T03:31:00Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Scientific Society |
| spelling | doaj.art-ce246f18a6d6466b95ddecaa8cc61e252022-12-22T03:04:28ZengWolters Kluwer Medknow PublicationsJournal of the Scientific Society0974-50092012-01-013917910.4103/0974-5009.96459Inducible clindamycin resistance in Staphylococci: Should clinicians and microbiologists be concerned?Madhumati KamatM A VagaraliS G KaradesaiThe increasing incidence of a variety of infections due to Staphylococcus aureus and the expanding role of community-associated methicillin-resistant S. aureus has led to an emphasis on the need for safe and effective agents to treat both systemic and localized Staphylococcal infections. Several newer antimicrobial agents are available for treatment of systemic Staphylococcal infections, but their use may be limited by the relatively high cost of these agents or the need forparenteral administration. Clindamycin has been used successfully to treat soft-tissue and musculoskeletal infections due to MRSA, in adults and children. However, concern over the possibility of the emergence of clindamycin resistance during therapy has discouraged some clinicians from prescribing that agent. Simple laboratory testing (e.g., the erythromycin-clindamycin ′D-zone′ test) can separate strains that have the genetic potential (i.e., the presence of erm genes) to become resistant during therapy, from strains that are fully susceptible to clindamycin.http://www.jscisociety.com/article.asp?issn=0974-5009;year=2012;volume=39;issue=1;spage=7;epage=9;aulast=KamatClindamycinD testerythromycininducibleS. aureus |
| spellingShingle | Madhumati Kamat M A Vagarali S G Karadesai Inducible clindamycin resistance in Staphylococci: Should clinicians and microbiologists be concerned? Journal of the Scientific Society Clindamycin D test erythromycin inducible S. aureus |
| title | Inducible clindamycin resistance in Staphylococci: Should clinicians and microbiologists be concerned? |
| title_full | Inducible clindamycin resistance in Staphylococci: Should clinicians and microbiologists be concerned? |
| title_fullStr | Inducible clindamycin resistance in Staphylococci: Should clinicians and microbiologists be concerned? |
| title_full_unstemmed | Inducible clindamycin resistance in Staphylococci: Should clinicians and microbiologists be concerned? |
| title_short | Inducible clindamycin resistance in Staphylococci: Should clinicians and microbiologists be concerned? |
| title_sort | inducible clindamycin resistance in staphylococci should clinicians and microbiologists be concerned |
| topic | Clindamycin D test erythromycin inducible S. aureus |
| url | http://www.jscisociety.com/article.asp?issn=0974-5009;year=2012;volume=39;issue=1;spage=7;epage=9;aulast=Kamat |
| work_keys_str_mv | AT madhumatikamat inducibleclindamycinresistanceinstaphylococcishouldcliniciansandmicrobiologistsbeconcerned AT mavagarali inducibleclindamycinresistanceinstaphylococcishouldcliniciansandmicrobiologistsbeconcerned AT sgkaradesai inducibleclindamycinresistanceinstaphylococcishouldcliniciansandmicrobiologistsbeconcerned |