Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses
A combined research approach using GWAS on Parkinson's disease patients and a Drosophila model of L-DOPA-induced dyskinesia (LID) reveals that LID is linked to ADCY2 signaling.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03830-x |
| _version_ | 1811285896422490112 |
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| author | Woongchang Yoon Soohong Min Ho-Sung Ryu Sun Ju Chung Jongkyeong Chung |
| author_facet | Woongchang Yoon Soohong Min Ho-Sung Ryu Sun Ju Chung Jongkyeong Chung |
| author_sort | Woongchang Yoon |
| collection | DOAJ |
| description | A combined research approach using GWAS on Parkinson's disease patients and a Drosophila model of L-DOPA-induced dyskinesia (LID) reveals that LID is linked to ADCY2 signaling. |
| first_indexed | 2024-04-13T02:51:38Z |
| format | Article |
| id | doaj.art-ce2693576ca748d48ef1a811a10d9e12 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T02:51:38Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-ce2693576ca748d48ef1a811a10d9e122022-12-22T03:05:50ZengNature PortfolioCommunications Biology2399-36422022-08-015111410.1038/s42003-022-03830-xDiscovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analysesWoongchang Yoon0Soohong Min1Ho-Sung Ryu2Sun Ju Chung3Jongkyeong Chung4School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National UniversitySchool of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National UniversityDepartment of Neurology, Kyungpook National University HospitalDepartment of Neurology, Asan Medical Center, University of Ulsan College of MedicineSchool of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National UniversityA combined research approach using GWAS on Parkinson's disease patients and a Drosophila model of L-DOPA-induced dyskinesia (LID) reveals that LID is linked to ADCY2 signaling.https://doi.org/10.1038/s42003-022-03830-x |
| spellingShingle | Woongchang Yoon Soohong Min Ho-Sung Ryu Sun Ju Chung Jongkyeong Chung Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses Communications Biology |
| title | Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses |
| title_full | Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses |
| title_fullStr | Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses |
| title_full_unstemmed | Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses |
| title_short | Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses |
| title_sort | discovery of levodopa induced dyskinesia associated genes using genomic studies in patients and drosophila behavioral analyses |
| url | https://doi.org/10.1038/s42003-022-03830-x |
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