Results of Evaluation of the Physical and Mechanical Properties of a New Suture Material with Miramistin Coating
Background: The imperfection of surgical sutures, from the point of view of insufficient prevention of microbial contamination in the area of suturing, is one of the urgent problems in modern practical healthcare. In this connection, one of the promising areas at the present time is the study of sut...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2022-06-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://www.ijbm.org/articles/i46/ijbm_12(2)_oa20.pdf |
| _version_ | 1818161866930651136 |
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| author | Anastasia V. Mosolova Boris S. Sukovatykh Maria A. Zatolokina Ekaterina S. Mishina Denis S. Tishkov Alexander A. Sozykin |
| author_facet | Anastasia V. Mosolova Boris S. Sukovatykh Maria A. Zatolokina Ekaterina S. Mishina Denis S. Tishkov Alexander A. Sozykin |
| author_sort | Anastasia V. Mosolova |
| collection | DOAJ |
| description | Background: The imperfection of surgical sutures, from the point of view of insufficient prevention of microbial contamination in the area of suturing, is one of the urgent problems in modern practical healthcare. In this connection, one of the promising areas at the present time is the study of suture material under conditions of its coating with various antiseptics. This study aimed to evaluate the physical and mechanical properties of the suture material impregnated with miramistin for further application in experimental studies on animals.
Methods and Results: By applying a two-layer polymer coating on absorbable polyglycolide threads, the threads were given antimicrobial properties. In the amount of 10% or 20% by weight of the polymer, miramistin was introduced into both coatings.
The breaking load and elongation data in the surgical suture knot were evaluated by immersing the samples in a phosphate buffer solution (pH=7.4), maintaining a constant temperature of 37°C by a thermostat. Threads from the solution were extracted on Days 1, 3, 7, 14, and 21 of the experiment. Further, the studied samples of the suture material were subjected to stretching to rupture on a universal tensile testing machine of the domestic company Metrotest. Physical and mechanical properties were evaluated by the dynamics of the breaking load and elongation at a break in the node after being in a phosphate buffer solution. Coating of polyglycolide thread, which is a suture material, with miramistin at a concentration of 10% and 20% does not lead to loss of strength even in the long term of the experimental study, which, in turn, meets the standards for suture material.
Conclusion: The results obtained allow us to recommend a suture material impregnated with miramistin for further research, the ultimate goal of which will be the possibility of active use of this material in practical medicine, in particular in surgery to prevent microbial contamination in the area of suturing and infection of wounds. |
| first_indexed | 2024-12-11T16:24:35Z |
| format | Article |
| id | doaj.art-ce26cd11e46f459d8077f216c887c76c |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-12-11T16:24:35Z |
| publishDate | 2022-06-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-ce26cd11e46f459d8077f216c887c76c2022-12-22T00:58:45ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292022-06-0112230831010.21103/Article12(2)_OA20Results of Evaluation of the Physical and Mechanical Properties of a New Suture Material with Miramistin CoatingAnastasia V. Mosolova0Boris S. Sukovatykh1Maria A. Zatolokina2Ekaterina S. Mishina3Denis S. Tishkov4Alexander A. Sozykin5Kursk State Medical University, Kursk, RussiaKursk State Medical University, Kursk, RussiaKursk State Medical University, Kursk, RussiaKursk State Medical University, Kursk, RussiaKursk State Medical University, Kursk, RussiaRostov State Medical University, Rostov-on-Don, RussiaBackground: The imperfection of surgical sutures, from the point of view of insufficient prevention of microbial contamination in the area of suturing, is one of the urgent problems in modern practical healthcare. In this connection, one of the promising areas at the present time is the study of suture material under conditions of its coating with various antiseptics. This study aimed to evaluate the physical and mechanical properties of the suture material impregnated with miramistin for further application in experimental studies on animals. Methods and Results: By applying a two-layer polymer coating on absorbable polyglycolide threads, the threads were given antimicrobial properties. In the amount of 10% or 20% by weight of the polymer, miramistin was introduced into both coatings. The breaking load and elongation data in the surgical suture knot were evaluated by immersing the samples in a phosphate buffer solution (pH=7.4), maintaining a constant temperature of 37°C by a thermostat. Threads from the solution were extracted on Days 1, 3, 7, 14, and 21 of the experiment. Further, the studied samples of the suture material were subjected to stretching to rupture on a universal tensile testing machine of the domestic company Metrotest. Physical and mechanical properties were evaluated by the dynamics of the breaking load and elongation at a break in the node after being in a phosphate buffer solution. Coating of polyglycolide thread, which is a suture material, with miramistin at a concentration of 10% and 20% does not lead to loss of strength even in the long term of the experimental study, which, in turn, meets the standards for suture material. Conclusion: The results obtained allow us to recommend a suture material impregnated with miramistin for further research, the ultimate goal of which will be the possibility of active use of this material in practical medicine, in particular in surgery to prevent microbial contamination in the area of suturing and infection of wounds.http://www.ijbm.org/articles/i46/ijbm_12(2)_oa20.pdfmiramistinsuture materialmicrobial contaminationbreaking loadbreaking elongation |
| spellingShingle | Anastasia V. Mosolova Boris S. Sukovatykh Maria A. Zatolokina Ekaterina S. Mishina Denis S. Tishkov Alexander A. Sozykin Results of Evaluation of the Physical and Mechanical Properties of a New Suture Material with Miramistin Coating International Journal of Biomedicine miramistin suture material microbial contamination breaking load breaking elongation |
| title | Results of Evaluation of the Physical and Mechanical Properties of a New Suture Material with Miramistin Coating |
| title_full | Results of Evaluation of the Physical and Mechanical Properties of a New Suture Material with Miramistin Coating |
| title_fullStr | Results of Evaluation of the Physical and Mechanical Properties of a New Suture Material with Miramistin Coating |
| title_full_unstemmed | Results of Evaluation of the Physical and Mechanical Properties of a New Suture Material with Miramistin Coating |
| title_short | Results of Evaluation of the Physical and Mechanical Properties of a New Suture Material with Miramistin Coating |
| title_sort | results of evaluation of the physical and mechanical properties of a new suture material with miramistin coating |
| topic | miramistin suture material microbial contamination breaking load breaking elongation |
| url | http://www.ijbm.org/articles/i46/ijbm_12(2)_oa20.pdf |
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