Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia

Abstract Current therapies that target the B-cell receptor pathway or the inhibition of anti-apoptotic proteins do not prevent the progressive forms of chronic lymphocytic leukemia (CLL), have low long-term efficacy and are subject to therapeutic resistance. Deciphering the mechanisms of leukemic ce...

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Bibliographic Details
Main Authors: Léa Ikhlef, May Yassine, Boutaîna Chandouri, Léa Rivière, Thomas Naves, Natalya Dmytruk, Nathalie Gachard, Marie-Odile Jauberteau, Paul-François Gallet
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-56663-5