PRMT5 inhibition disrupts splicing and stemness in glioblastoma
The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a usefu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21204-5 |
| _version_ | 1818754052178051072 |
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| author | Patty Sachamitr Jolene C. Ho Felipe E. Ciamponi Wail Ba-Alawi Fiona J. Coutinho Paul Guilhamon Michelle M. Kushida Florence M. G. Cavalli Lilian Lee Naghmeh Rastegar Victoria Vu María Sánchez-Osuna Jasmin Coulombe-Huntington Evgeny Kanshin Heather Whetstone Mathieu Durand Philippe Thibault Kirsten Hart Maria Mangos Joseph Veyhl Wenjun Chen Nhat Tran Bang-Chi Duong Ahmed M. Aman Xinghui Che Xiaoyang Lan Owen Whitley Olga Zaslaver Dalia Barsyte-Lovejoy Laura M. Richards Ian Restall Amy Caudy Hannes L. Röst Zahid Quyoom Bonday Mark Bernstein Sunit Das Michael D. Cusimano Julian Spears Gary D. Bader Trevor J. Pugh Mike Tyers Mathieu Lupien Benjamin Haibe-Kains H. Artee Luchman Samuel Weiss Katlin B. Massirer Panagiotis Prinos Cheryl H. Arrowsmith Peter B. Dirks |
| author_facet | Patty Sachamitr Jolene C. Ho Felipe E. Ciamponi Wail Ba-Alawi Fiona J. Coutinho Paul Guilhamon Michelle M. Kushida Florence M. G. Cavalli Lilian Lee Naghmeh Rastegar Victoria Vu María Sánchez-Osuna Jasmin Coulombe-Huntington Evgeny Kanshin Heather Whetstone Mathieu Durand Philippe Thibault Kirsten Hart Maria Mangos Joseph Veyhl Wenjun Chen Nhat Tran Bang-Chi Duong Ahmed M. Aman Xinghui Che Xiaoyang Lan Owen Whitley Olga Zaslaver Dalia Barsyte-Lovejoy Laura M. Richards Ian Restall Amy Caudy Hannes L. Röst Zahid Quyoom Bonday Mark Bernstein Sunit Das Michael D. Cusimano Julian Spears Gary D. Bader Trevor J. Pugh Mike Tyers Mathieu Lupien Benjamin Haibe-Kains H. Artee Luchman Samuel Weiss Katlin B. Massirer Panagiotis Prinos Cheryl H. Arrowsmith Peter B. Dirks |
| author_sort | Patty Sachamitr |
| collection | DOAJ |
| description | The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a useful therapeutic strategy |
| first_indexed | 2024-12-18T05:17:07Z |
| format | Article |
| id | doaj.art-ce276d7ef43841fc91a953ffc3d02ecd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:17:07Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ce276d7ef43841fc91a953ffc3d02ecd2022-12-21T21:19:45ZengNature PortfolioNature Communications2041-17232021-02-0112111710.1038/s41467-021-21204-5PRMT5 inhibition disrupts splicing and stemness in glioblastomaPatty Sachamitr0Jolene C. Ho1Felipe E. Ciamponi2Wail Ba-Alawi3Fiona J. Coutinho4Paul Guilhamon5Michelle M. Kushida6Florence M. G. Cavalli7Lilian Lee8Naghmeh Rastegar9Victoria Vu10María Sánchez-Osuna11Jasmin Coulombe-Huntington12Evgeny Kanshin13Heather Whetstone14Mathieu Durand15Philippe Thibault16Kirsten Hart17Maria Mangos18Joseph Veyhl19Wenjun Chen20Nhat Tran21Bang-Chi Duong22Ahmed M. Aman23Xinghui Che24Xiaoyang Lan25Owen Whitley26Olga Zaslaver27Dalia Barsyte-Lovejoy28Laura M. Richards29Ian Restall30Amy Caudy31Hannes L. Röst32Zahid Quyoom Bonday33Mark Bernstein34Sunit Das35Michael D. Cusimano36Julian Spears37Gary D. Bader38Trevor J. Pugh39Mike Tyers40Mathieu Lupien41Benjamin Haibe-Kains42H. Artee Luchman43Samuel Weiss44Katlin B. Massirer45Panagiotis Prinos46Cheryl H. Arrowsmith47Peter B. Dirks48Developmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenStructural Genomics Consortium, University of TorontoCenter for Molecular Biology and Genetic Engineering, University of Campinas (UNICAMP)Princess Margaret Cancer Centre, University Health NetworkDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenStructural Genomics Consortium, University of TorontoInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenRNomics Platform, Université de SherbrookeRNomics Platform, Université de SherbrookeStructural Genomics Consortium, University of TorontoStructural Genomics Consortium, University of TorontoStructural Genomics Consortium, University of TorontoStructural Genomics Consortium, University of TorontoStructural Genomics Consortium, University of TorontoStructural Genomics Consortium, University of TorontoOntario Institute for Cancer ResearchDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenThe Donnelly Centre, University of TorontoThe Donnelly Centre, University of TorontoStructural Genomics Consortium, University of TorontoPrincess Margaret Cancer Centre, University Health NetworkHotchkiss Brain Institute, Cumming School of Medicine, University of CalgaryThe Donnelly Centre, University of TorontoThe Donnelly Centre, University of TorontoLilly Research Laboratories, Eli Lilly and CompanyDivision of Neurosurgery, Department of Surgery, University of TorontoDivision of Neurosurgery, Department of Surgery, University of TorontoDivision of Neurosurgery, Department of Surgery, St. Michael’s HospitalDivision of Neurosurgery, Department of Surgery, University of TorontoThe Donnelly Centre, University of TorontoPrincess Margaret Cancer Centre, University Health NetworkInstitute for Research in Immunology and Cancer, Université de MontréalPrincess Margaret Cancer Centre, University Health NetworkPrincess Margaret Cancer Centre, University Health NetworkHotchkiss Brain Institute, Cumming School of Medicine, University of CalgaryHotchkiss Brain Institute, Cumming School of Medicine, University of CalgaryCenter for Molecular Biology and Genetic Engineering, University of Campinas (UNICAMP)Structural Genomics Consortium, University of TorontoStructural Genomics Consortium, University of TorontoDevelopmental and Stem Cell Biology Program and Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick ChildrenThe arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a useful therapeutic strategyhttps://doi.org/10.1038/s41467-021-21204-5 |
| spellingShingle | Patty Sachamitr Jolene C. Ho Felipe E. Ciamponi Wail Ba-Alawi Fiona J. Coutinho Paul Guilhamon Michelle M. Kushida Florence M. G. Cavalli Lilian Lee Naghmeh Rastegar Victoria Vu María Sánchez-Osuna Jasmin Coulombe-Huntington Evgeny Kanshin Heather Whetstone Mathieu Durand Philippe Thibault Kirsten Hart Maria Mangos Joseph Veyhl Wenjun Chen Nhat Tran Bang-Chi Duong Ahmed M. Aman Xinghui Che Xiaoyang Lan Owen Whitley Olga Zaslaver Dalia Barsyte-Lovejoy Laura M. Richards Ian Restall Amy Caudy Hannes L. Röst Zahid Quyoom Bonday Mark Bernstein Sunit Das Michael D. Cusimano Julian Spears Gary D. Bader Trevor J. Pugh Mike Tyers Mathieu Lupien Benjamin Haibe-Kains H. Artee Luchman Samuel Weiss Katlin B. Massirer Panagiotis Prinos Cheryl H. Arrowsmith Peter B. Dirks PRMT5 inhibition disrupts splicing and stemness in glioblastoma Nature Communications |
| title | PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_full | PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_fullStr | PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_full_unstemmed | PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_short | PRMT5 inhibition disrupts splicing and stemness in glioblastoma |
| title_sort | prmt5 inhibition disrupts splicing and stemness in glioblastoma |
| url | https://doi.org/10.1038/s41467-021-21204-5 |
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