Alteration of N6-Methyladenosine mRNA Methylation in a Human Stem Cell-Derived Cardiomyocyte Model of Tyrosine Kinase Inhibitor-Induced Cardiotoxicity

Alteration of N6-Methyladenosine mRNA Methylation in a Human Stem Cell-Derived Cardiomyocyte Model of Tyrosine Kinase Inhibitor-Induced Cardiotoxicity

BackgroundN6-methyladenosine (m6A) plays important roles in various cardiovascular diseases (CVDs), including cardiac hypertrophy and heart failure. Sunitinib (SUN) is a tyrosine kinase inhibitor (TKI) that is widely used in the treatment of different types of solid and blood tumors, but its efficac...

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Bibliographic Details
Main Authors: Yan Ma, Xian Liu, Yiming Bi, Tianhu Wang, Cheng Chen, Yabin Wang, Dong Han, Feng Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
tyrosine kinase inhibitor (TKI)
hiPSC-CMs
N6-methyladenosine
FTO
cardiotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.849175/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.849175/full

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