The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health, sleep and quality of life, especially in individuals with chronic disease. Therefore, the purpose of this systematic review and meta-analysis was to investigate the impact of the COVID-19 pandemic on...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03176-9 |
| _version_ | 1797845903060500480 |
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| author | Marcos Paulo Braz de Oliveira Ana Emilia Fonseca de Castro Andressa Leticia Miri Carla Rigo Lima Brendon David Truax Vanessa Suziane Probst Suhaila Mahmoud Smaili |
| author_facet | Marcos Paulo Braz de Oliveira Ana Emilia Fonseca de Castro Andressa Leticia Miri Carla Rigo Lima Brendon David Truax Vanessa Suziane Probst Suhaila Mahmoud Smaili |
| author_sort | Marcos Paulo Braz de Oliveira |
| collection | DOAJ |
| description | Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health, sleep and quality of life, especially in individuals with chronic disease. Therefore, the purpose of this systematic review and meta-analysis was to investigate the impact of the COVID-19 pandemic on neuropsychiatric disorders (depression, anxiety, stress), sleep disorders (sleep quality, insomnia) and quality of life in individuals with Parkinson’s disease (PD), Multiple Sclerosis (MS) and Alzheimer's disease (AD) compared to healthy controls. Methods Seven databases (Medline, Embase, ScienceDirect, Web of Science, The Cochrane Library, Scielo and Lilacs) were searched between March 2020 and December 2022. Observational studies (i.e., cross-sectional, case–control, cohort) were included. GRADE approach was used to assess the quality of evidence and strength of the recommendation. Effect size was calculated using standardized mean differences (SMD; random effects model). A customized Downs and Black checklist was used to assess the risk of bias. Results Eighteen studies (PD = 7, MS = 11) were included. A total of 627 individuals with PD (healthy controls = 857) and 3923 individuals with MS (healthy controls = 2432) were analyzed. Twelve studies (PD = 4, MS = 8) were included in the meta-analysis. Individuals with PD had significantly elevated levels of depression (very low evidence, SMD = 0.40, p = 0.04) and stress (very low evidence, SMD = 0.60, p < 0.0001). There was no difference in anxiety (p = 0.08). Individuals with MS had significantly higher levels of depression (very low evidence, SMD = 0.73, p = 0.007) and stress (low evidence, SMD = 0.69, p = 0.03) and low quality of life (very low evidence, SMD = 0.77, p = 0.006). There was no difference in anxiety (p = 0.05) and sleep quality (p = 0.13). It was not possible to synthesize evidence in individuals with AD and sleep disorder (insomnia). Conclusion In general, the COVID-19 pandemic negatively impacted individuals with PD and MS. Individuals with PD showed significantly higher levels of depression and stress; and individuals with MS presented significantly higher depression and stress levels, as well as significantly lower quality of life when compared to healthy controls. Further studies are needed to investigate the impact of the COVID-19 pandemic in individuals with AD. |
| first_indexed | 2024-04-09T17:47:35Z |
| format | Article |
| id | doaj.art-ce29d1dc8f1e4f12b2fb13a89bb4c711 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-09T17:47:35Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-ce29d1dc8f1e4f12b2fb13a89bb4c7112023-04-16T11:17:31ZengBMCBMC Neurology1471-23772023-04-0123111910.1186/s12883-023-03176-9The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studiesMarcos Paulo Braz de Oliveira0Ana Emilia Fonseca de Castro1Andressa Leticia Miri2Carla Rigo Lima3Brendon David Truax4Vanessa Suziane Probst5Suhaila Mahmoud Smaili6Healthy Aging Research Laboratory, Department of Physical Therapy, Federal University of São CarlosPhysical Therapy Laboratory, Department of Physical Therapy, State University of CampinasNeurofunctional Physical Therapy Research Group, Department of Physical Therapy, State University of LondrinaMechanisms of Spinal Manual Therapy Laboratory, Department of Physical Therapy, The University of Alabama at BirminghamDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, The University of Alabama at BirminghamNeurofunctional Physical Therapy Research Group, Department of Physical Therapy, State University of LondrinaNeurofunctional Physical Therapy Research Group, Department of Physical Therapy, State University of LondrinaAbstract Background The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health, sleep and quality of life, especially in individuals with chronic disease. Therefore, the purpose of this systematic review and meta-analysis was to investigate the impact of the COVID-19 pandemic on neuropsychiatric disorders (depression, anxiety, stress), sleep disorders (sleep quality, insomnia) and quality of life in individuals with Parkinson’s disease (PD), Multiple Sclerosis (MS) and Alzheimer's disease (AD) compared to healthy controls. Methods Seven databases (Medline, Embase, ScienceDirect, Web of Science, The Cochrane Library, Scielo and Lilacs) were searched between March 2020 and December 2022. Observational studies (i.e., cross-sectional, case–control, cohort) were included. GRADE approach was used to assess the quality of evidence and strength of the recommendation. Effect size was calculated using standardized mean differences (SMD; random effects model). A customized Downs and Black checklist was used to assess the risk of bias. Results Eighteen studies (PD = 7, MS = 11) were included. A total of 627 individuals with PD (healthy controls = 857) and 3923 individuals with MS (healthy controls = 2432) were analyzed. Twelve studies (PD = 4, MS = 8) were included in the meta-analysis. Individuals with PD had significantly elevated levels of depression (very low evidence, SMD = 0.40, p = 0.04) and stress (very low evidence, SMD = 0.60, p < 0.0001). There was no difference in anxiety (p = 0.08). Individuals with MS had significantly higher levels of depression (very low evidence, SMD = 0.73, p = 0.007) and stress (low evidence, SMD = 0.69, p = 0.03) and low quality of life (very low evidence, SMD = 0.77, p = 0.006). There was no difference in anxiety (p = 0.05) and sleep quality (p = 0.13). It was not possible to synthesize evidence in individuals with AD and sleep disorder (insomnia). Conclusion In general, the COVID-19 pandemic negatively impacted individuals with PD and MS. Individuals with PD showed significantly higher levels of depression and stress; and individuals with MS presented significantly higher depression and stress levels, as well as significantly lower quality of life when compared to healthy controls. Further studies are needed to investigate the impact of the COVID-19 pandemic in individuals with AD.https://doi.org/10.1186/s12883-023-03176-9Parkinson diseaseMultiple sclerosisAlzheimer diseaseCOVID-19Systematic reviewMeta-analysis |
| spellingShingle | Marcos Paulo Braz de Oliveira Ana Emilia Fonseca de Castro Andressa Leticia Miri Carla Rigo Lima Brendon David Truax Vanessa Suziane Probst Suhaila Mahmoud Smaili The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies BMC Neurology Parkinson disease Multiple sclerosis Alzheimer disease COVID-19 Systematic review Meta-analysis |
| title | The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies |
| title_full | The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies |
| title_fullStr | The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies |
| title_full_unstemmed | The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies |
| title_short | The impact of the COVID-19 pandemic on neuropsychiatric and sleep disorders, and quality of life in individuals with neurodegenerative and demyelinating diseases: a systematic review and meta-analysis of observational studies |
| title_sort | impact of the covid 19 pandemic on neuropsychiatric and sleep disorders and quality of life in individuals with neurodegenerative and demyelinating diseases a systematic review and meta analysis of observational studies |
| topic | Parkinson disease Multiple sclerosis Alzheimer disease COVID-19 Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12883-023-03176-9 |
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