Pyroptosis-Mediated Periodontal Disease
Pyroptosis is a caspase-dependent process relevant to the understanding of beneficial host responses and medical conditions for which inflammation is central to the pathophysiology of the disease. Pyroptosis has been recently suggested as one of the pathways of exacerbated inflammation of periodonta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/1/372 |
| _version_ | 1797498835374702592 |
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| author | Mariane Beatriz Sordi Ricardo de Souza Magini Layla Panahipour Reinhard Gruber |
| author_facet | Mariane Beatriz Sordi Ricardo de Souza Magini Layla Panahipour Reinhard Gruber |
| author_sort | Mariane Beatriz Sordi |
| collection | DOAJ |
| description | Pyroptosis is a caspase-dependent process relevant to the understanding of beneficial host responses and medical conditions for which inflammation is central to the pathophysiology of the disease. Pyroptosis has been recently suggested as one of the pathways of exacerbated inflammation of periodontal tissues. Hence, this focused review aims to discuss pyroptosis as a pathological mechanism in the cause of periodontitis. The included articles presented similarities regarding methods, type of cells applied, and cell stimulation, as the outcomes also point to the same direction considering the cellular events. The collected data indicate that virulence factors present in the diseased periodontal tissues initiate the inflammasome route of tissue destruction with caspase activation, cleavage of gasdermin D, and secretion of interleukins IL-1β and IL-18. Consequently, removing periopathogens’ virulence factors that trigger pyroptosis is a potential strategy to combat periodontal disease and regain tissue homeostasis. |
| first_indexed | 2024-03-10T03:39:03Z |
| format | Article |
| id | doaj.art-ce2a057a2709470e81f917869eff321e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:39:03Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ce2a057a2709470e81f917869eff321e2023-11-23T11:39:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0123137210.3390/ijms23010372Pyroptosis-Mediated Periodontal DiseaseMariane Beatriz Sordi0Ricardo de Souza Magini1Layla Panahipour2Reinhard Gruber3Department of Oral Biology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Dentistry, Federal University of Santa Catarina, Florianopolis 88040-900, BrazilDepartment of Oral Biology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Oral Biology, Medical University of Vienna, 1090 Vienna, AustriaPyroptosis is a caspase-dependent process relevant to the understanding of beneficial host responses and medical conditions for which inflammation is central to the pathophysiology of the disease. Pyroptosis has been recently suggested as one of the pathways of exacerbated inflammation of periodontal tissues. Hence, this focused review aims to discuss pyroptosis as a pathological mechanism in the cause of periodontitis. The included articles presented similarities regarding methods, type of cells applied, and cell stimulation, as the outcomes also point to the same direction considering the cellular events. The collected data indicate that virulence factors present in the diseased periodontal tissues initiate the inflammasome route of tissue destruction with caspase activation, cleavage of gasdermin D, and secretion of interleukins IL-1β and IL-18. Consequently, removing periopathogens’ virulence factors that trigger pyroptosis is a potential strategy to combat periodontal disease and regain tissue homeostasis.https://www.mdpi.com/1422-0067/23/1/372pyroptosisimmune responseinflammationperiodontal diseaseperiodontitis |
| spellingShingle | Mariane Beatriz Sordi Ricardo de Souza Magini Layla Panahipour Reinhard Gruber Pyroptosis-Mediated Periodontal Disease International Journal of Molecular Sciences pyroptosis immune response inflammation periodontal disease periodontitis |
| title | Pyroptosis-Mediated Periodontal Disease |
| title_full | Pyroptosis-Mediated Periodontal Disease |
| title_fullStr | Pyroptosis-Mediated Periodontal Disease |
| title_full_unstemmed | Pyroptosis-Mediated Periodontal Disease |
| title_short | Pyroptosis-Mediated Periodontal Disease |
| title_sort | pyroptosis mediated periodontal disease |
| topic | pyroptosis immune response inflammation periodontal disease periodontitis |
| url | https://www.mdpi.com/1422-0067/23/1/372 |
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