Paradigm shift in vertebral eosinophilic granuloma
Objective: Eosinophilic granuloma is the most common type of Langerhans cell histiocytosis. Vertebral bone involvement of eosinophilic granuloma is a rare disease. There are few studies in the literature on patients with vertebral bone involvement diagnosed with eosinophilic granuloma. Th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Romodanov Neurosurgery Institute
2023-03-01
|
| Series: | Ukrainian Neurosurgical Journal |
| Online Access: | https://theunj.org/article/view/268336 |
| _version_ | 1797351456851886080 |
|---|---|
| author | Muhammet Arif Ozbek Veyselkarani Ipek Cem Dinс |
| author_facet | Muhammet Arif Ozbek Veyselkarani Ipek Cem Dinс |
| author_sort | Muhammet Arif Ozbek |
| collection | DOAJ |
| description |
Objective: Eosinophilic granuloma is the most common type of Langerhans cell histiocytosis. Vertebral bone involvement of eosinophilic granuloma is a rare disease. There are few studies in the literature on patients with vertebral bone involvement diagnosed with eosinophilic granuloma. There is still no clear protocol for the treatment of patients with vertebral involvement with eosinophilic granuloma. This article is a summary of the clinical follow-ups of our 6 cases diagnosed with spinal eosinophilic granuloma. We changed the chemotherapy protocol or extended the duration of chemotherapy in patients with progressive disease.Methods: In this study, there are six patients (4 male and 2 female) with vertebral involvement of eosinophilic granuloma in our hospital between September 2017 and August 2022. The clinical findings, radiological images, treatments and follow-up results of the patients were analyzed retrospectively.Results: In the follow-ups, a new vertebral bone involvement was observed in two patients and a femoral bone involvement was observed in another patient. One patient with neurological deficit underwent surgical treatment. Chemotherapy treatment was given to four patients with multiple bone involvement or recurrence. No recurrence was observed in three patients who started chemotherapy treatment after recurrence.Conclusions: Surgical treatment should be considered in patients with neurological deficits and spinal instability. According to the results of our study, patients with multiple bone or systemic involvement and no neurological deficit should receive chemotherapy treatment. We recommend changing the chemotherapy protocol or extending the chemotherapy duration in patients with progressive disease. |
| first_indexed | 2024-03-08T12:59:43Z |
| format | Article |
| id | doaj.art-ce2c4ebe1cb6434d82279f65cb71c07f |
| institution | Directory Open Access Journal |
| issn | 2663-9084 2663-9092 |
| language | English |
| last_indexed | 2024-03-08T12:59:43Z |
| publishDate | 2023-03-01 |
| publisher | Romodanov Neurosurgery Institute |
| record_format | Article |
| series | Ukrainian Neurosurgical Journal |
| spelling | doaj.art-ce2c4ebe1cb6434d82279f65cb71c07f2024-01-19T11:04:09ZengRomodanov Neurosurgery InstituteUkrainian Neurosurgical Journal2663-90842663-90922023-03-01291303710.25305/unj.268336Paradigm shift in vertebral eosinophilic granulomaMuhammet Arif Ozbek0https://orcid.org/0000-0002-1847-2562Veyselkarani Ipek1https://orcid.org/0000-0002-8617-9958Cem Dinс2https://orcid.org/0000-0003-1295-5528Istanbul Medipol University, Istanbul, TurkeyIstanbul Medipol University, Istanbul, TurkeyIstanbul Medipol University, Istanbul, Turkey Objective: Eosinophilic granuloma is the most common type of Langerhans cell histiocytosis. Vertebral bone involvement of eosinophilic granuloma is a rare disease. There are few studies in the literature on patients with vertebral bone involvement diagnosed with eosinophilic granuloma. There is still no clear protocol for the treatment of patients with vertebral involvement with eosinophilic granuloma. This article is a summary of the clinical follow-ups of our 6 cases diagnosed with spinal eosinophilic granuloma. We changed the chemotherapy protocol or extended the duration of chemotherapy in patients with progressive disease.Methods: In this study, there are six patients (4 male and 2 female) with vertebral involvement of eosinophilic granuloma in our hospital between September 2017 and August 2022. The clinical findings, radiological images, treatments and follow-up results of the patients were analyzed retrospectively.Results: In the follow-ups, a new vertebral bone involvement was observed in two patients and a femoral bone involvement was observed in another patient. One patient with neurological deficit underwent surgical treatment. Chemotherapy treatment was given to four patients with multiple bone involvement or recurrence. No recurrence was observed in three patients who started chemotherapy treatment after recurrence.Conclusions: Surgical treatment should be considered in patients with neurological deficits and spinal instability. According to the results of our study, patients with multiple bone or systemic involvement and no neurological deficit should receive chemotherapy treatment. We recommend changing the chemotherapy protocol or extending the chemotherapy duration in patients with progressive disease.https://theunj.org/article/view/268336 |
| spellingShingle | Muhammet Arif Ozbek Veyselkarani Ipek Cem Dinс Paradigm shift in vertebral eosinophilic granuloma Ukrainian Neurosurgical Journal |
| title | Paradigm shift in vertebral eosinophilic granuloma |
| title_full | Paradigm shift in vertebral eosinophilic granuloma |
| title_fullStr | Paradigm shift in vertebral eosinophilic granuloma |
| title_full_unstemmed | Paradigm shift in vertebral eosinophilic granuloma |
| title_short | Paradigm shift in vertebral eosinophilic granuloma |
| title_sort | paradigm shift in vertebral eosinophilic granuloma |
| url | https://theunj.org/article/view/268336 |
| work_keys_str_mv | AT muhammetarifozbek paradigmshiftinvertebraleosinophilicgranuloma AT veyselkaraniipek paradigmshiftinvertebraleosinophilicgranuloma AT cemdins paradigmshiftinvertebraleosinophilicgranuloma |