Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extent

Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extent

Central nervous system (CNS) manifestations of plasma cell neoplasms are exceedingly uncommon. CNS multiple myeloma (MM) carries a dismal prognosis, and limited evidence exists to guide management of these patients. We report on 3 adult patients with plasma cell neoplasms that presented with CNS man...

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Bibliographic Details
Main Authors: Kyle McGrath, Graeme A. Fenton, Robert P. Seifert, Keith R. Peters, John W. Hiemenz, Erin A. Dean
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Current Problems in Cancer: Case Reports
Subjects:
Intracranial plasma cell neoplasms
Solitary plasmacytoma
Multiple myeloma
Frontline therapy
Autologous hematopoietic stem cell transplant
Online Access:http://www.sciencedirect.com/science/article/pii/S2666621923000315
Description
Summary:Central nervous system (CNS) manifestations of plasma cell neoplasms are exceedingly uncommon. CNS multiple myeloma (MM) carries a dismal prognosis, and limited evidence exists to guide management of these patients. We report on 3 adult patients with plasma cell neoplasms that presented with CNS manifestations. After summarizing their clinical presentation along with radiologic and pathologic findings, we focus on the patients’ differential management depending on extent of disease while reviewing the literature on frontline therapy in this rare disease scenario.
ISSN:2666-6219

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