Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extent
Central nervous system (CNS) manifestations of plasma cell neoplasms are exceedingly uncommon. CNS multiple myeloma (MM) carries a dismal prognosis, and limited evidence exists to guide management of these patients. We report on 3 adult patients with plasma cell neoplasms that presented with CNS man...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Current Problems in Cancer: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621923000315 |
| _version_ | 1797676580443521024 |
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| author | Kyle McGrath Graeme A. Fenton Robert P. Seifert Keith R. Peters John W. Hiemenz Erin A. Dean |
| author_facet | Kyle McGrath Graeme A. Fenton Robert P. Seifert Keith R. Peters John W. Hiemenz Erin A. Dean |
| author_sort | Kyle McGrath |
| collection | DOAJ |
| description | Central nervous system (CNS) manifestations of plasma cell neoplasms are exceedingly uncommon. CNS multiple myeloma (MM) carries a dismal prognosis, and limited evidence exists to guide management of these patients. We report on 3 adult patients with plasma cell neoplasms that presented with CNS manifestations. After summarizing their clinical presentation along with radiologic and pathologic findings, we focus on the patients’ differential management depending on extent of disease while reviewing the literature on frontline therapy in this rare disease scenario. |
| first_indexed | 2024-03-11T22:31:17Z |
| format | Article |
| id | doaj.art-ce2d960b51604a899652517f73d332d6 |
| institution | Directory Open Access Journal |
| issn | 2666-6219 |
| language | English |
| last_indexed | 2024-03-11T22:31:17Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj.art-ce2d960b51604a899652517f73d332d62023-09-23T05:12:50ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192023-09-0111100247Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extentKyle McGrath0Graeme A. Fenton1Robert P. Seifert2Keith R. Peters3John W. Hiemenz4Erin A. Dean5College of Medicine, University of Florida, Gainesville, FL, USACollege of Medicine, University of Florida, Gainesville, FL, USADepartment of Pathology, University of Florida, Gainesville, FL, USADepartment of Radiology, University of Florida, Gainesville, FL, USADepartment of Medicine, Division of Hematology and Oncology, University of Florida, Gainesville, FL, USADepartment of Medicine, Division of Hematology and Oncology, University of Florida, Gainesville, FL, USA; Corresponding author.Central nervous system (CNS) manifestations of plasma cell neoplasms are exceedingly uncommon. CNS multiple myeloma (MM) carries a dismal prognosis, and limited evidence exists to guide management of these patients. We report on 3 adult patients with plasma cell neoplasms that presented with CNS manifestations. After summarizing their clinical presentation along with radiologic and pathologic findings, we focus on the patients’ differential management depending on extent of disease while reviewing the literature on frontline therapy in this rare disease scenario.http://www.sciencedirect.com/science/article/pii/S2666621923000315Intracranial plasma cell neoplasmsSolitary plasmacytomaMultiple myelomaFrontline therapyAutologous hematopoietic stem cell transplant |
| spellingShingle | Kyle McGrath Graeme A. Fenton Robert P. Seifert Keith R. Peters John W. Hiemenz Erin A. Dean Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extent Current Problems in Cancer: Case Reports Intracranial plasma cell neoplasms Solitary plasmacytoma Multiple myeloma Frontline therapy Autologous hematopoietic stem cell transplant |
| title | Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extent |
| title_full | Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extent |
| title_fullStr | Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extent |
| title_full_unstemmed | Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extent |
| title_short | Central nervous system manifestations as initial presentation of plasma cell disorders: Differential management of 3 cases based on disease extent |
| title_sort | central nervous system manifestations as initial presentation of plasma cell disorders differential management of 3 cases based on disease extent |
| topic | Intracranial plasma cell neoplasms Solitary plasmacytoma Multiple myeloma Frontline therapy Autologous hematopoietic stem cell transplant |
| url | http://www.sciencedirect.com/science/article/pii/S2666621923000315 |
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