Long-term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma: a population-based study of 1514 patients
Abstract Rectal mucinous adenocarcinoma (RMAC) is a rare and aggressive form of rectal cancer. The effectiveness of neoadjuvant radiotherapy (NRT) for RMAC has not been well studied, and the survival benefit remains controversial. The purpose of this work was to determine the prognostic role of NRT...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38846-8 |
| _version_ | 1797774247792214016 |
|---|---|
| author | Can Chen Xi Chen Jingting Jiang |
| author_facet | Can Chen Xi Chen Jingting Jiang |
| author_sort | Can Chen |
| collection | DOAJ |
| description | Abstract Rectal mucinous adenocarcinoma (RMAC) is a rare and aggressive form of rectal cancer. The effectiveness of neoadjuvant radiotherapy (NRT) for RMAC has not been well studied, and the survival benefit remains controversial. The purpose of this work was to determine the prognostic role of NRT in patients with RMAC by propensity-score matching (PSM). A retrospective cohort study using the Surveillance, Epidemiology, and End Results from 2004 to 2015 was performed. In the multivariate analysis before PSM, NRT provided better OS (HR 0.61, 95% CI 0.52–0.71, p < 0.001) and CSS (HR 0.68, 95% CI 0.56–0.82, p < 0.001). Multivariate analysis after PSM (n = 844) confirmed that patients receiving NRT survived longer than those without NRT (OS: HR 0.60, 95% CI 0.50–0.78, p < 0.001 and CSS: HR 0.68, 95% CI 0.54–0.84, p < 0.001). Subgroup analysis indicated that NRT had significantly improved OS and CSS in stage II RMAC and OS in stage III RMAC after adjusting for various confounding factors. |
| first_indexed | 2024-03-12T22:18:15Z |
| format | Article |
| id | doaj.art-ce2dc06a7325469c8d691360a6eb5f76 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T22:18:15Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ce2dc06a7325469c8d691360a6eb5f762023-07-23T11:13:00ZengNature PortfolioScientific Reports2045-23222023-07-0113111110.1038/s41598-023-38846-8Long-term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma: a population-based study of 1514 patientsCan Chen0Xi Chen1Jingting Jiang2Department of Oncology, The Third Affiliated Hospital of Soochow UniversityDepartment of Dermatology, The First Affiliated Hospital of Huzhou UniversityDepartment of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow UniversityAbstract Rectal mucinous adenocarcinoma (RMAC) is a rare and aggressive form of rectal cancer. The effectiveness of neoadjuvant radiotherapy (NRT) for RMAC has not been well studied, and the survival benefit remains controversial. The purpose of this work was to determine the prognostic role of NRT in patients with RMAC by propensity-score matching (PSM). A retrospective cohort study using the Surveillance, Epidemiology, and End Results from 2004 to 2015 was performed. In the multivariate analysis before PSM, NRT provided better OS (HR 0.61, 95% CI 0.52–0.71, p < 0.001) and CSS (HR 0.68, 95% CI 0.56–0.82, p < 0.001). Multivariate analysis after PSM (n = 844) confirmed that patients receiving NRT survived longer than those without NRT (OS: HR 0.60, 95% CI 0.50–0.78, p < 0.001 and CSS: HR 0.68, 95% CI 0.54–0.84, p < 0.001). Subgroup analysis indicated that NRT had significantly improved OS and CSS in stage II RMAC and OS in stage III RMAC after adjusting for various confounding factors.https://doi.org/10.1038/s41598-023-38846-8 |
| spellingShingle | Can Chen Xi Chen Jingting Jiang Long-term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma: a population-based study of 1514 patients Scientific Reports |
| title | Long-term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma: a population-based study of 1514 patients |
| title_full | Long-term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma: a population-based study of 1514 patients |
| title_fullStr | Long-term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma: a population-based study of 1514 patients |
| title_full_unstemmed | Long-term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma: a population-based study of 1514 patients |
| title_short | Long-term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma: a population-based study of 1514 patients |
| title_sort | long term effect of neoadjuvant radiotherapy in patients with locally advanced rectal mucinous adenocarcinoma a population based study of 1514 patients |
| url | https://doi.org/10.1038/s41598-023-38846-8 |
| work_keys_str_mv | AT canchen longtermeffectofneoadjuvantradiotherapyinpatientswithlocallyadvancedrectalmucinousadenocarcinomaapopulationbasedstudyof1514patients AT xichen longtermeffectofneoadjuvantradiotherapyinpatientswithlocallyadvancedrectalmucinousadenocarcinomaapopulationbasedstudyof1514patients AT jingtingjiang longtermeffectofneoadjuvantradiotherapyinpatientswithlocallyadvancedrectalmucinousadenocarcinomaapopulationbasedstudyof1514patients |