Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker

Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker

Molecular and functional characterization of alveolar epithelial type I (AT1) cells has been challenging due to difficulty in isolating sufficient numbers of viable cells. Here we performed single-cell RNA-sequencing (scRNA-seq) of tdTomato<sup>+</sup> cells from lungs of AT1 cell-specif...

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Bibliographic Details
Main Authors: Masafumi Horie, Alessandra Castaldi, Mitsuhiro Sunohara, Hongjun Wang, Yanbin Ji, Yixin Liu, Fan Li, Thomas A. Wilkinson, Long Hung, Hua Shen, Hidenori Kage, Ite A. Offringa, Crystal N. Marconett, Per Flodby, Beiyun Zhou, Zea Borok
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
aquaporin 5 (AQP5)
alveolar epithelial type 1 cell
scRNA-seq
GPRC5A
AT1 cell marker
Online Access:https://www.mdpi.com/2073-4409/9/11/2460

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