Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess
Background Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA. Methods...
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PeerJ Inc.
2023-10-01
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| author | Li Liu Shaohua Liu Meng Hao Song Hu Tian Yu Yunkai Yang Zhelong Liu |
| author_facet | Li Liu Shaohua Liu Meng Hao Song Hu Tian Yu Yunkai Yang Zhelong Liu |
| author_sort | Li Liu |
| collection | DOAJ |
| description | Background Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA. Methods A total of 154 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, Hubei, China) between October 2011 and June 2021 were included in this retrospective analysis. Muscle-fat related indicators were measured by computed tomography (CT) images at the third lumbar vertebra (L3) level. The data of patients between the sarcopenia group and non-sarcopenia group were compared. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed. Results The skeletal muscle index (SMI) was independently associated with adverse outcomes (95% CI [0.649–0.954], P = 0.015) of PLA in multivariate logistic regression analysis. This conclusion held true in sex-specific subgroup analysis. ROC analysis indicated that SMI may predict adverse outcomes in both male (area under the ROC curve [AUC], 0.718; cut-off, 52.59; P < 0.001) and female (AUC, 0.714; cut-off, 38.39; P = 0.017) patient populations. Conclusions Sarcopenia serves as an independent risk factor for poor prognosis in PLA and patients with sarcopenia may be more prone to adverse outcomes. |
| first_indexed | 2024-03-09T05:02:27Z |
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| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T05:02:27Z |
| publishDate | 2023-10-01 |
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| spelling | doaj.art-ce312e1d09934d9f915feb42cbb0e52b2023-12-03T12:59:17ZengPeerJ Inc.PeerJ2167-83592023-10-0111e1605510.7717/peerj.16055Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscessLi Liu0Shaohua Liu1Meng Hao2Song Hu3Tian Yu4Yunkai Yang5Zhelong Liu6Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastroenterology, Zigui County People’s Hospital, Yichang, ChinaDepartment of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaEight-year Program of Clinical Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBackground Low muscle mass/sarcopenia has been associated with poor prognosis in many diseases, but its clinical significance in pyogenic liver abscess (PLA) remains unclear. The purpose of this study is to investigate the relationship between muscle mass and prognosis of patients with PLA. Methods A total of 154 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, Hubei, China) between October 2011 and June 2021 were included in this retrospective analysis. Muscle-fat related indicators were measured by computed tomography (CT) images at the third lumbar vertebra (L3) level. The data of patients between the sarcopenia group and non-sarcopenia group were compared. Multivariate logistic regression and receiver operating characteristic (ROC) curve analyses were performed. Results The skeletal muscle index (SMI) was independently associated with adverse outcomes (95% CI [0.649–0.954], P = 0.015) of PLA in multivariate logistic regression analysis. This conclusion held true in sex-specific subgroup analysis. ROC analysis indicated that SMI may predict adverse outcomes in both male (area under the ROC curve [AUC], 0.718; cut-off, 52.59; P < 0.001) and female (AUC, 0.714; cut-off, 38.39; P = 0.017) patient populations. Conclusions Sarcopenia serves as an independent risk factor for poor prognosis in PLA and patients with sarcopenia may be more prone to adverse outcomes.https://peerj.com/articles/16055.pdfPyogenic liver abscessSarcopeniaMuscle massBody compositionPrognosisRetrospective |
| spellingShingle | Li Liu Shaohua Liu Meng Hao Song Hu Tian Yu Yunkai Yang Zhelong Liu Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess PeerJ Pyogenic liver abscess Sarcopenia Muscle mass Body composition Prognosis Retrospective |
| title | Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess |
| title_full | Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess |
| title_fullStr | Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess |
| title_full_unstemmed | Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess |
| title_short | Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess |
| title_sort | sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess |
| topic | Pyogenic liver abscess Sarcopenia Muscle mass Body composition Prognosis Retrospective |
| url | https://peerj.com/articles/16055.pdf |
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