ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity
Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in Adarexpression impairs normal waking in flies.
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10512 |
| _version_ | 1819040430661042176 |
|---|---|
| author | J. E. Robinson J. Paluch D. K. Dickman W. J. Joiner |
| author_facet | J. E. Robinson J. Paluch D. K. Dickman W. J. Joiner |
| author_sort | J. E. Robinson |
| collection | DOAJ |
| description | Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in Adarexpression impairs normal waking in flies. |
| first_indexed | 2024-12-21T09:08:59Z |
| format | Article |
| id | doaj.art-ce31aae827ab426bb26dbf8945633928 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:08:59Z |
| publishDate | 2016-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ce31aae827ab426bb26dbf89456339282022-12-21T19:09:16ZengNature PortfolioNature Communications2041-17232016-01-01711910.1038/ncomms10512ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticityJ. E. Robinson0J. Paluch1D. K. Dickman2W. J. Joiner3Department of Pharmacology, University of California San DiegoDepartment of Neurobiology, University of Southern CaliforniaDepartment of Neurobiology, University of Southern CaliforniaDepartment of Pharmacology, University of California San DiegoSleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in Adarexpression impairs normal waking in flies.https://doi.org/10.1038/ncomms10512 |
| spellingShingle | J. E. Robinson J. Paluch D. K. Dickman W. J. Joiner ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity Nature Communications |
| title | ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity |
| title_full | ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity |
| title_fullStr | ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity |
| title_full_unstemmed | ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity |
| title_short | ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity |
| title_sort | adar mediated rna editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity |
| url | https://doi.org/10.1038/ncomms10512 |
| work_keys_str_mv | AT jerobinson adarmediatedrnaeditingsuppressessleepbyactingasabrakeonglutamatergicsynapticplasticity AT jpaluch adarmediatedrnaeditingsuppressessleepbyactingasabrakeonglutamatergicsynapticplasticity AT dkdickman adarmediatedrnaeditingsuppressessleepbyactingasabrakeonglutamatergicsynapticplasticity AT wjjoiner adarmediatedrnaeditingsuppressessleepbyactingasabrakeonglutamatergicsynapticplasticity |