| Summary: | Bacterial infections, especially those in hospital settings, represent a major complication of COVID-19 patients, complicating management and worsening clinical outcomes. <i>Corynebacterium striatum</i> is a non-diphtheric actinobacterium that has been reported as being the causative agent of several different infections, affecting both immunocompetent and immunocompromised patients. Recently, <i>C. striatum</i> has been recognized as a nosocomial pathogen that is responsible for severe infection in critical patients, as well as in fragile and immunocompromised subjects. <i>C. striatum</i> has been described as the etiological agent of bacteremia, central line infections, and endocarditis. We report a case of a 91-year-old woman who was hospitalized due to SARS-CoV-2 infection, who developed <i>C. striatum</i> bacteremia and died despite antimicrobial therapy and clinical efforts. Furthermore, we discuss <i>C. striatum</i> diagnosis and treatment based on evidence from the scientific literature.
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