Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells

Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells

Background: An emerging body of evidence indicates an association between anthropogenic particulate matter (PM) and neurodegeneration. Although the historical focus of PM toxicity has been on the cardiopulmonary system, ultrafine PM particles can also exert detrimental effects in the brain. However,...

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Bibliographic Details
Main Authors: Silvia Sapienza, Valentina Tedeschi, Barbara Apicella, Francesco Palestra, Carmela Russo, Ilaria Piccialli, Anna Pannaccione, Stefania Loffredo, Agnese Secondo
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
ultrafine particles
air pollution
TRPML1
autophagy
motor neurons
neurotoxicity
Online Access:https://www.mdpi.com/1422-0067/23/21/13041

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