Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923

Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923

In this paper, we report studies concerning four variants of the G-quadruplex forming anti-HIV-integrase aptamer T30923, in which specific 2′-deoxyguanosines have been singly replaced by 8-methyl-2′-deoxyguanosine residues, with the aim to exploit the methyl group positioned in the G-quadruplex groo...

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Bibliographic Details
Main Authors: Veronica Esposito, Francesca Esposito, Antonietta Pepe, Isabel Gomez Monterrey, Enzo Tramontano, Luciano Mayol, Antonella Virgilio, Aldo Galeone
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplex
8-methyl-2′-deoxyguanosine
aptamers
integrase
HIV
Online Access:https://www.mdpi.com/1422-0067/21/16/5637

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