Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells

Summary: Relapse of acute myeloid leukemia (AML) remains a significant concern due to persistent leukemia-initiating stem cells (LICs) that are typically not targeted by most existing therapies. Using a murine AML model, human AML cell lines, and patient samples, we show that AML LICs are sensitive...

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Main Authors: Fenghua Qian, Shaneice K. Nettleford, Jiayan Zhou, Brooke E. Arner, Molly A. Hall, Arati Sharma, Charyguly Annageldiyev, Randy M. Rossi, Diwakar B. Tukaramrao, Deborpita Sarkar, Shailaja Hegde, Ujjawal H. Gandhi, Emily R. Finch, Laura Goodfield, Michael D. Quickel, David F. Claxton, Robert F. Paulson, K. Sandeep Prabhu
格式: Article
語言:English
出版: Elsevier 2023-07-01
叢編:Cell Reports
主題:
CP: Cancer
在線閱讀:http://www.sciencedirect.com/science/article/pii/S2211124723008057

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http://www.sciencedirect.com/science/article/pii/S2211124723008057

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