Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis
Abstract Background In patients with axial spondyloarthritis, vertebral fracture risk is elevated and not always correlated with bone mineral density (BMD). Trabecular bone score (TBS) may offer some advantages in the assessment of vertebral fracture risk in these patients. The primary objective of...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-023-06431-9 |
| _version_ | 1797841248558514176 |
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| author | Elia Valls-Pascual Ana Victoria Orenes-Vera Ana Sendra-García Àngels Martínez-Ferrer Lydia Montolío-Chiva Ignacio Vázquez-Gómez Eduardo Flores-Fernández Desamparados Ybáñez-García María Vega-Martínez Luis García-Ferrer Magdalena Graells-Ferrer Juan José Alegre-Sancho |
| author_facet | Elia Valls-Pascual Ana Victoria Orenes-Vera Ana Sendra-García Àngels Martínez-Ferrer Lydia Montolío-Chiva Ignacio Vázquez-Gómez Eduardo Flores-Fernández Desamparados Ybáñez-García María Vega-Martínez Luis García-Ferrer Magdalena Graells-Ferrer Juan José Alegre-Sancho |
| author_sort | Elia Valls-Pascual |
| collection | DOAJ |
| description | Abstract Background In patients with axial spondyloarthritis, vertebral fracture risk is elevated and not always correlated with bone mineral density (BMD). Trabecular bone score (TBS) may offer some advantages in the assessment of vertebral fracture risk in these patients. The primary objective of this study was to compare TBS and BMD between axial spondyloarthritis patients depending on their vertebral fracture status. Secondary objectives were to estimate the prevalence of morphometric vertebral fractures, and to explore factors associated with fracture, as well as the interference of syndesmophytes on BMD and TBS. Methods A cross-sectional study was conducted. Data were collected on demographic and clinical characteristics, lab results, imaging findings and treatment. Statistical analysis was performed using SPSS v.13 statistical software. Results Eighty-four patients (60 men and 24 women; mean age of 59 years) were included. Nearly half (47.6%) of them had lumbar syndesmophytes. The rate of morphometric fracture was 11.9%. TBS showed a higher area under the curve (0.89) than total hip, femoral neck and lumbar BMD (0.80, 0.78, and 0.70 respectively) for classifying patients regarding their fracture status. Nonetheless, the differences did not reach statistical significance. Syndesmophytes affected lumbar spine BMD (p < 0.001), but not hip BMD or TBS. Fractures were associated with TBS, total hip BMD, erythrocyte sedimentation rate and C-reactive protein levels. Conclusions We identified decreased TBS and total hip BMD, as well as increased erythrocyte sedimentation rate and C-reactive protein levels as factors associated with morphometric vertebral fractures. Unlike lumbar spine BMD, TBS is not affected by the presence of syndesmophytes. |
| first_indexed | 2024-04-09T16:27:53Z |
| format | Article |
| id | doaj.art-ce38ba02e9bf452dbc5e173cab7b8cf7 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-09T16:27:53Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-ce38ba02e9bf452dbc5e173cab7b8cf72023-04-23T11:03:38ZengBMCBMC Musculoskeletal Disorders1471-24742023-04-012411810.1186/s12891-023-06431-9Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritisElia Valls-Pascual0Ana Victoria Orenes-Vera1Ana Sendra-García2Àngels Martínez-Ferrer3Lydia Montolío-Chiva4Ignacio Vázquez-Gómez5Eduardo Flores-Fernández6Desamparados Ybáñez-García7María Vega-Martínez8Luis García-Ferrer9Magdalena Graells-Ferrer10Juan José Alegre-Sancho11Rheumatology Department, Doctor Peset University HospitalRheumatology Department, Arnau de Vilanova University HospitalPharmacy Department, Doctor Peset University HospitalRheumatology Department, Doctor Peset University HospitalRheumatology Department, University General Hospital of CastellónRheumatology Department, Doctor Peset University HospitalRheumatology Department, Doctor Peset University HospitalRheumatology Department, Doctor Peset University HospitalRadiology Department, Doctor Peset University HospitalRadiology Department, Doctor Peset University HospitalRadiology Department, Doctor Peset University HospitalRheumatology Department, Doctor Peset University HospitalAbstract Background In patients with axial spondyloarthritis, vertebral fracture risk is elevated and not always correlated with bone mineral density (BMD). Trabecular bone score (TBS) may offer some advantages in the assessment of vertebral fracture risk in these patients. The primary objective of this study was to compare TBS and BMD between axial spondyloarthritis patients depending on their vertebral fracture status. Secondary objectives were to estimate the prevalence of morphometric vertebral fractures, and to explore factors associated with fracture, as well as the interference of syndesmophytes on BMD and TBS. Methods A cross-sectional study was conducted. Data were collected on demographic and clinical characteristics, lab results, imaging findings and treatment. Statistical analysis was performed using SPSS v.13 statistical software. Results Eighty-four patients (60 men and 24 women; mean age of 59 years) were included. Nearly half (47.6%) of them had lumbar syndesmophytes. The rate of morphometric fracture was 11.9%. TBS showed a higher area under the curve (0.89) than total hip, femoral neck and lumbar BMD (0.80, 0.78, and 0.70 respectively) for classifying patients regarding their fracture status. Nonetheless, the differences did not reach statistical significance. Syndesmophytes affected lumbar spine BMD (p < 0.001), but not hip BMD or TBS. Fractures were associated with TBS, total hip BMD, erythrocyte sedimentation rate and C-reactive protein levels. Conclusions We identified decreased TBS and total hip BMD, as well as increased erythrocyte sedimentation rate and C-reactive protein levels as factors associated with morphometric vertebral fractures. Unlike lumbar spine BMD, TBS is not affected by the presence of syndesmophytes.https://doi.org/10.1186/s12891-023-06431-9Trabecular bone scoreBone mineral densityAxial spondyloarthritisSyndesmophytesVertebral fracture |
| spellingShingle | Elia Valls-Pascual Ana Victoria Orenes-Vera Ana Sendra-García Àngels Martínez-Ferrer Lydia Montolío-Chiva Ignacio Vázquez-Gómez Eduardo Flores-Fernández Desamparados Ybáñez-García María Vega-Martínez Luis García-Ferrer Magdalena Graells-Ferrer Juan José Alegre-Sancho Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis BMC Musculoskeletal Disorders Trabecular bone score Bone mineral density Axial spondyloarthritis Syndesmophytes Vertebral fracture |
| title | Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis |
| title_full | Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis |
| title_fullStr | Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis |
| title_full_unstemmed | Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis |
| title_short | Relationship between trabecular bone score, bone mineral density and vertebral fractures in patients with axial spondyloarthritis |
| title_sort | relationship between trabecular bone score bone mineral density and vertebral fractures in patients with axial spondyloarthritis |
| topic | Trabecular bone score Bone mineral density Axial spondyloarthritis Syndesmophytes Vertebral fracture |
| url | https://doi.org/10.1186/s12891-023-06431-9 |
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